A rare solid variant of primary neuroendocrine carcinoma of breast

Authors

  • Sahil I Panjvani Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Minesh B Gandhi Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Bhawana R Chaudhari Smt. NHL Municipal Medical College, Ahmedabad. India.
  • Ankur N Sarvaiya Smt. NHL Municipal Medical College, Ahmedabad. India.

Keywords:

Neuroendocrine carcinoma, chromogranin, synaptophysin, tumor.

Abstract

Solid Primary Neuroendocrine Carcinoma of Breast (NECB) is an extremely rare tumor of breast. Much less is known about it because of only few reported cases. Immunohistochemical examination showing expression of chromogranin and/or synoptophysin in more than 50% of cell population confirms evidence of neuroendocrine carcinoma. Here, we describe a case of 70-years old patient with brief review of clinopathological features, treatment and prognosis of solid NECB. Microscopy Solid islands of tumor cells are separated by fibrovascular stroma. Tumor cells are round to oval, polygonal with finely granular (stippled) nuclear chromatin with eosinophilic cytoplasm and immunohistochemistry reveal strong and cytoplasmic positivity for synaptophysin in  >50% tumor cell population. 

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Published

10-05-2015

How to Cite

1.
Panjvani SI, Gandhi MB, Chaudhari BR, Sarvaiya AN. A rare solid variant of primary neuroendocrine carcinoma of breast. Ann of Pathol and Lab Med [Internet]. 2015 May 10 [cited 2024 Nov. 22];2(2):C101-105. Available from: http://pacificejournals.com/journal/index.php/apalm/article/view/199

Issue

Vol. 2 No. 2 (2015)

Section

Case Report

License

Copyright (c) 2015 Sahil I Panjvani, Minesh B Gandhi, Bhawana R Chaudhari, Ankur N Sarvaiya

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