Progressive Transformation of Germinal Centers
A Mimicker of Lymphoma
DOI:
https://doi.org/10.21276/apalm.2046Keywords:
Follicular lymphoma, Hodgkin’s lymphoma, Lymph node, Progressive transformation of germinal centers.Abstract
Progressive transformation of germinal centers (PTGC) is an uncommon variant of non-specific reactive follicular hyperplasia. PTGC is a clinically asymptomatic condition characterised by persistent lymphadenopathy. PTGC may occur before, concurrently with or after the onset of nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL). It may also be confused for follicular lymphoma and mantle zone lymphoma. We report an interesting case of PTGC in a 23 year female with swelling in the left side of neck of one year duration. Histology revealed PTGC, which was confirmed by immunohistochemistry which showed CD3+, CD20+ in appropriate B and T cell region and negative for CD15, CD30 and bcl-2. As PTGC mimics lymphoma, it should be followed up carefully.
References
2. Brauninger A, Yang W, Wacker HH, RajewskyK, Kuppers R, Hansmann ML. B-cell development in progressive transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocytic-predominant Hodgkin disease. Blood. 2001Feb 1;97(3):714-9.
3. Sweetenham JW, Polliack A. Progressive transformation of germinal centers and Hodgkin lymphoma: more insights but may be more confusion? Leukemia & Lymphoma 2011; 52: 2041-2.
4. Ioachim Hl, Medeiros LJ. Ioachim’s Lymph node pathology. 4th eds Philadelphia: Lippincott Williams and Wilkins; 2009:186-9.
5. Hansmann ML, Fellbaum C, Hui PK, Moubayed P. Progressive transformation of germinal centers with or without association to Hodgkin’s disease. Am J Clin Pathol. 1990;93:219-226.
6. Roca B, Roca M, Zaragoza M, Martinez T , Diaz D. A case of progressive transformation of germinal centers in an HIV- infected patient. Austin journal of Microbiology;20151(2): 1-2.
7. Rosai J. Rosai and Ackerman’s Surgical Pathology.10th edition, St. Louis:Elsevier;2015: 1888-9.
8. Barbara M, Osborne MD, Butler JJ. Follicular lymphoma mimicking Progressive transformation of germinal centers. Am J Clin Pathol. 1987;88(3):264-269.
9. Kojima M, Nakamura S, Motoori T, Itoh H, Shimizu K, Yamane N et al . Progressive transformation of germinal centers: A clinicopathological study of 42 Japenese patients. International journal of surgical pathology. 2003;11(2):101-107.
10. Smith LB. Nodular Lymphocyte Predominant Hodgkin Lymphoma Diagnostic pearls and pitfalls. Arch Pathol Lab Med. 2010;134:1434-1439.
11. Brown JR, Skarin AT. Clinical Mimics of Lymphoma. The Oncologist 2004;9:406-416.
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Copyright (c) 2018 Sumaya ., Meena N Jadhav, Rashmi K Patil, Shreekant K Kittur
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