Assessment of Correlation Between HLA-B27 Associated Ankylosing Spondylitis With Acute Anterior Uveitis
DOI:
https://doi.org/10.21276/apalm.2094Keywords:
Ankylosing spondylitis, acute anterior uveitis, HLA-B27, Major Histocompatibility ComplexAbstract
Background-
Human leukocyte antigen HLA -B27 is a class I surface antigen which is encoded by the B locus on the chromosome number 6 in the major histocompatibility complex (MHC) . HLA –B27 antigen is associated with various seronegative arthropathies comprising of Ankylosing spondylitis, reactive arthritis, psoriatic arthritis and inflammatory bowel disease along with acute anterior uveitis. Main aim of our study is to analyze the correlation between the HLA -B27 associated Ankylosing spondylitis and uveitis.
Method-
Hundred patients with clinical symptoms and signs of Ankylosing spondylitis and Acute Anterior Uveitis were selected for the study and the blood samples were studied for flowcytometric analysis of HLA-B27/7.
Result-
Study suggests that patient of AS and positive HLA-B27 antigen have higher incidence of Acute anterior uveitis as compared to patients with AS and negative status of HLA- B27 antigen.
Conclusion-
Study suggests that HLA-B27 antigen is associated with both the clinical conditions, Ankylosing spondylitis and uveitis and these two clinical condition are closely related to each other.
References
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Copyright (c) 2018 Sachin Sharma, C.V. Kulkarni, Ashok Yadav, Sweta Tripathi, Gaurav Shelgaonkar
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