Cytological diagnosis of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: report of three cases
Keywords:
Exocrine pancreas, Giant cell tumor, Carcinoma, FNAC, OGCTAbstract
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is a very rare, highly malignant tumor of the exocrine pancreas and only few cases, diagnosed by Fine needle aspiration cytology (FNAC) have been reported till date. This tumor consists of two distinct cell populations composed of numerous multinucleated giant cells resembling osteoclasts of the bone and mononuclear stromal cells. Other heterogeneous cell populations may be present. We report three such cases in young patients with abdominal mass /digestive problems and rapid weight loss. Diagnoses were primarily made by FNAC and eventually confirmed by histopathology in tertiary centers.
References
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2. Watanabe M, Miura H, Inoue H et al. Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: histochemical and immunohistochemical study with review of the literature. Pancreas 1997; 15:201–8.
3. Chopra S, Wu ML, Imagawa DK, Lee J, Gu M. Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review. Diagn Cytopathol 2007; 35:601–6.
4. Gao L, Li ZS, Jin ZD, Man XH, Zhang MH, Zhu MH. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasonography-guided fine-needle aspiration. Chin Med J 2009;122:1598-1600
5. Shanthakumari S, Priya S, K Rajeshwari M. FNA diagnosis of osteoclast-like giant cell tumor of the pancreas. J Cytol 2012; 29: 270-2.
6. Kloppel G, Hruban RH, Longnecker DS. Ductal adenocarcinoma of pancreas. In: Hamilton SR, Aaltonen LA, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press; 2000.
7. Takeyuki Wada, Osamu Itano, Go Oshima et al. A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature. World J Surg Oncol 2011; 9:100.
8. Verbeke CS, Menon KV. Osteoclast-like giant cell tumour of the pancreas: an undifferentiated carcinoma of duct epithelial origin. Pancreatol 2006; 6: 254.
9. Sakai Y, Kupelioglu AA, Yanagisawa A et al. Origin of giant cells in osteoclast-like giant cell tumors of the pancreas. Hum Pathol 2000; 31: 1223-29.
10. Nai GA, Amico E, Gimenez VR, Guilmar M. Osteoclast-like giant cell tumor of the pancreas associated with mucus-secreting adenocarcinoma. Case report and discussion of the histogenesis. Pancreatol 2005; 5: 279-84.
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Published
10-05-2015
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Samanta S, Sharma SK. Cytological diagnosis of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: report of three cases. Ann of Pathol and Lab Med [Internet]. 2015 May 10 [cited 2024 Nov. 22];2(2):C125-129. Available from: http://pacificejournals.com/journal/index.php/apalm/article/view/37
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Copyright (c) 2015 Swapan Samanta, S. K. Sharma
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