The Degree Of Dysplasia in Neutrophils With a Special Note On Pelger- Huët Anomaly.
Keywords:
Pelger-Huët anomaly, pseudo- Pelger-Huët anomaly, dysplastic neutrophils, LeptospirosisAbstract
The Pelger- Huët anomaly (PHA), an autosomal dominant condition ,is characterized by morphologically abnormal neutrophil. This article summarizes the history of PHA , pathogenesis and guidance for differentiating congenital or acquired PHA, with their different morphological variants. We report an interesting case of pseudo-PHA in a 70 year old male diagnosed with Leptospirosis, showing unilobed, unilobed intended, bilobed pelgeroid cells in the peripheral smear.
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DOI:Â 10.21276/APALM.2017.990
References
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10. Shetty VT, Mundle SD, Raza A. Pseudo Pelger-Huet anomaly in myelodysplastic syndrome: Hyposegmented apoptotic neutrophil?. Blood 2001; 98: 1273–1275.
11. Economopoulou C, Pappa V, Kontsioti F, et al. Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS). Leuk Res 2008; 32: 61–69.
12. Lee S, Khankhanian P, Salama C et al. Int J Hematol 2015;102(1): 129-33.
13.Colella R , Hollensead SC. Understanding and Recognizing the Pelger-Huët Anomaly. Am J Clin Pathol 2012;137(3):358-66.
2. Skendzel LP, Hoffman GC. The pelger anomaly of leukocytes: Forty-one cases in seven families. Am J Clin Pathol 1962; 37: 294–301.
3. Cunningham JM, Patnaik MM, Hammerschmidt DE, et al. Historical perspective and clinical implications of the Pelger-Huët cell. Am J Hematol 2009; 84:116–119.
4. Best S, Salvati F, Kallo J, et al. Lamin B-receptor mutations in Pelger-Huët anomaly. Br J Haematol. 2003 ; 123(3):542-4.
5.Hoffmann K, Dreger CK, Olins AL et al. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly). Nat Genet 2002;31: 410–414.
6. Oosterwijk JC, Mansour S, van Noort G. Congenital abnormalities reported in Pelger-Huët homozygosity as compared to Greenberg/HEM dysplasia: highly variable expression of allelic phenotypes. J Med Genet 2003; 40:937–41.
7. Borovik L, Modaff P, Waterham HR, et al. Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR. Am J Med Genet A 2013; 161A:2066–73.
8. Guido D’Angelo. The Pelger-Huet Anomaly. From morphology to clinical suspicion. International Journal of Clinical Medicine Research 2014; 4:125-27.
9. Ayan MS. Pseudo Pelger-Huet abnormality: case report. Reactions. 2015 ;1573:137
10. Shetty VT, Mundle SD, Raza A. Pseudo Pelger-Huet anomaly in myelodysplastic syndrome: Hyposegmented apoptotic neutrophil?. Blood 2001; 98: 1273–1275.
11. Economopoulou C, Pappa V, Kontsioti F, et al. Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS). Leuk Res 2008; 32: 61–69.
12. Lee S, Khankhanian P, Salama C et al. Int J Hematol 2015;102(1): 129-33.
13.Colella R , Hollensead SC. Understanding and Recognizing the Pelger-Huët Anomaly. Am J Clin Pathol 2012;137(3):358-66.
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Published
18-02-2017
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Thajudeen AS, Prasaad PR. The Degree Of Dysplasia in Neutrophils With a Special Note On Pelger- Huët Anomaly. Ann of Pathol and Lab Med [Internet]. 2017 Feb. 18 [cited 2024 Nov. 23];4(1):C18-21. Available from: http://pacificejournals.com/journal/index.php/apalm/article/view/apalm990
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Copyright (c) 2017 Ayeesha Sithika Thajudeen, Priavadhana Rajan Prasaad
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