Study of Glycated hemoglobin level in Non-Diabetic Iron deficiency anemia
Keywords:
Anemia, Glycated hemoglobin, Non diabetic, HbA1c
Abstract
Background: The traditional role of HbA1c analysis has been for assessing glycaemic control in patients with diabetes. The results of seminal studies demonstrated that early, intensive glycaemic control could significantly reduce the risk of a range of diabetes-related complications, and permitted the establishment of precise HbA1c target values for treatment goals.Methods: Study involves total Total 140 partcipants and among them 70 are non-diabetic, anaemic patients and 70 age-matched healthy subjects. Haematologic investigations were done and the fasting and postprandial glucose and HbA1c levels were measured in all the subjects. Result: The mean HbA1c (9.1 ± 1.7%) level in the patients with IDA was higher than that in the control group (5.5% ± 0.8) (p < 0.05). There were no differences in the levels of fasting and postprandial glucose between the IDA and the control groups (p > 0.05). Conclusion: HbA1c is not affected by the blood sugar levels alone, and there are various confounding factors when HbA1c is measured, especially that of iron deficiency, which is the commonest of the deficiency diseases worldwide. It is hence important to rule out IDA before making a therapeutic decision, based on the HbA1c levels.References
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2) Telen MJ, Kaufman RE. The mature erythrocyte. In: Greer JP, Forester J, et al., editors. Wintrobe's clinical hematology. 11th ed. Lippincot: Williams and Wilkins; 2004. pp. 230.
3) American Diabetes Association. Position statement: Standards of medical care in diabetes-2007. Diabetes Care 2007;30 S1:S9
4) Shekhar H, Mangukiya K, Kaur A, Jadeja P. Effect of iron deficiency anemia on glycation of haemoglobin in nondiabetics, I.J.S.N., 2014; 5(3) 477-79
5) El-Agouza I, Abu Shola A, Sirdah M. The effect of iron defiiciency anaemia on the levels of the haemoglobin subtypes: the possible consequences in a clinical diagnosis. Clin Lab Haematol.; 2002;24:285e9
6) Brooks AP, Metcalfe J, Day JL, Edwards MS. Iron defiiciency and glycosylated haemoglobin A1. Lancet. 1980;19(ii):141
7) Hansen PG, Eriksen J, Andersen TM, Olesen L. Glycosylated hae-moglobin (HbA1c) in iron and vitamin B12 deficiency. J Intern Med. 1990; 227:133–36
8) Horton BF, Huisman TH. Studies on the heterogeneity of haemoglobin. VII. Minor haemoglobin components in haematological diseases. Br J Haematol. 1965; 11: 296–304.
9) Brooks AP, Metcalfe J, Day JL, Edwards MS. Iron deficiency and glycosylated haemoglobin A. Lancet.1980;2:141
10) Davis RE, McCann VJ, Nicol DJ. Influence of iron-deficiency anaemia on the glycosylated haemoglobin level in a patient with diabetes mellitus. Med J Aust. 1983; 1: 40–1.
11) van Heyningen C, Dalton RG. Glycosylated haemoglobin in iron-deficiency anaemia. Lancet. 1985; 1:874.
12) Rai KB, Pattabiraman TN. Glycosylated haemoglobin levels in iron deficiency anaemia. Indian J MedRes.1986;83:234–6
13) Sluiter WJ, van Essen LH, Reitsma WD, Doorenbos H. Glycosylated haemoglobin and iron deficiency. Lancet 1980;2:531–532
14) Saudek CD, Herman WH, Sacks DB, Bergenstal RM, Edelman D, Davidson MB. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab. 2008; 93: 2447–53
Published
13-12-2016
Section
Original Article
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