An unusual case of Nerve sheath myxoma with schwannomatous and perineural differentiation
Keywords:
Benign tumour, Nerve sheath myxoma, S100 protein, EMAAbstract
Nerve sheath myxoma (NSM) is a rare benign tumour of peripheral nerves. It is seen in middle aged adults with slight female predilection and presents as a slow growing painless mass. The commonest sites are extremities, scalp, back and neck. Microscopically it has a typical morphological appearance. It is multilobulated and is composed of spindle and stellate shaped cells set in an abundant myxoid stroma. The cells show strong positivity for S-100 protein and are EMA negative or it stains only few perineural cells, indicating its close relationship with schwannoma or neurofibroma. But we report a rare case of nerve sheath myxoma in a 40 year old woman which showed typical microscopic features of NSM. However it showed an unusual co-expression of S100 and EMA indicating a bidirectional schwannomatous-perineural differentiation. The clinicopathological features, various differential diagnosis, its histogenesis and brief review of literature are discussed below.
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Copyright (c) 2016 Smitha Surendra Masamatti, Aparna Narasimha, Jayalakshmi Valligari Janardhan
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