Spinal Cord Compression due to Extra Medullary Hematopoiesis in a Case Of Thalassemia Minor
A Rare Case Report
DOI:
https://doi.org/10.21276/apalm.1745Keywords:
Extramedullary Hematopoiesis, Spinal Cord Compression, Thalassemia Minor, ReviewAbstract
Extra medullary Hematopoiesis occurs as a result of inefficient erythropoiesis in several conditions. Para spinal Involvement is rare and it produces morbid consequences due to spinal cord compression. We present a very rare case of patient with Thalassemia Minor having Extra medullary Hematopoiesis causing Spinal cord compression followed by a detailed review of literature regarding the clinical, radiological and pathological features and treatment modalities of Extra medullary Hematopoiesis affecting predominantly the spinal region in patients with Thalassemia.
References
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2. Singhal S, Sharma S, Dixit S, De S, Chander S, Rath GK, et al. The role of radiation therapy in the management of spinal cord compression due to extramedullary hematopoiesis in thalassaemia. J Neurol Neurosurg Psychiatry. 1992 Apr;55(4):310-2.(7)
3. Soman S, Rosenfeld DL, Roychowdhury S, Drachtman RA, Cohler A. Cord Compression due to Extramedullary Hematopoiesis in an Adolescent with Known Beta Thalassemia Major. J Radiol Case Rep. 2009 Jan4;3(1):17-22.(4)
4. Haidar R, Mhaidli H, Taher AT. Paraspinal extramedullary hematopoiesis in patients with thalassemia intermedia. Eur Spine J. 2010 Jun 5;19(6):871-8.(5)
5. Zhang H-Z, Li Y, Liu X, Chen B-R, Yao G-H, Peng Y-N. Extramedullary hematopoiesis: A report of two cases. Exp Ther Med. 2016 Dec 2;12(6):3859-62.(6)
6. Ito S, Fujita N, Hosogane N, Nagoshi N, Yagi M, Iwanami A, et al. Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera. Case Rep Orthop. 2017;2017:2416365.(8)
7. Musallam KM, Taher AT, Rachmilewitz EA. β-thalassemia intermedia: a clinical perspective. Cold Spring Harb Perspect Med. 2012 Jul 18;2(7):a013482.(9)
8. Koch CA, Li C-Y, Mesa RA, Tefferi A. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 2003 Oct;78(10):1223-33(10)
9. Cervantes D B, E G-T, J S-L, V A-M, R R-C, J S-G. Extramedullary Hematopoiesis in a Non- Transfused Elderly Patient Diagnosed with Beta Thalassemia Minor. J Hematol Blood Disord. 2015;1(1):2-4.(12)
10. Lalueza A, Silva CP, Alcalá-Galiano A, Arrieta E, Cánovas JM, Calero MR, et al. Presacral and intrathoracic extramedullary hematopoiesis in a patient with β thalassemia minor. Clin Respir J . 2016 May 5(13)
2. Singhal S, Sharma S, Dixit S, De S, Chander S, Rath GK, et al. The role of radiation therapy in the management of spinal cord compression due to extramedullary hematopoiesis in thalassaemia. J Neurol Neurosurg Psychiatry. 1992 Apr;55(4):310-2.(7)
3. Soman S, Rosenfeld DL, Roychowdhury S, Drachtman RA, Cohler A. Cord Compression due to Extramedullary Hematopoiesis in an Adolescent with Known Beta Thalassemia Major. J Radiol Case Rep. 2009 Jan4;3(1):17-22.(4)
4. Haidar R, Mhaidli H, Taher AT. Paraspinal extramedullary hematopoiesis in patients with thalassemia intermedia. Eur Spine J. 2010 Jun 5;19(6):871-8.(5)
5. Zhang H-Z, Li Y, Liu X, Chen B-R, Yao G-H, Peng Y-N. Extramedullary hematopoiesis: A report of two cases. Exp Ther Med. 2016 Dec 2;12(6):3859-62.(6)
6. Ito S, Fujita N, Hosogane N, Nagoshi N, Yagi M, Iwanami A, et al. Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera. Case Rep Orthop. 2017;2017:2416365.(8)
7. Musallam KM, Taher AT, Rachmilewitz EA. β-thalassemia intermedia: a clinical perspective. Cold Spring Harb Perspect Med. 2012 Jul 18;2(7):a013482.(9)
8. Koch CA, Li C-Y, Mesa RA, Tefferi A. Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 2003 Oct;78(10):1223-33(10)
9. Cervantes D B, E G-T, J S-L, V A-M, R R-C, J S-G. Extramedullary Hematopoiesis in a Non- Transfused Elderly Patient Diagnosed with Beta Thalassemia Minor. J Hematol Blood Disord. 2015;1(1):2-4.(12)
10. Lalueza A, Silva CP, Alcalá-Galiano A, Arrieta E, Cánovas JM, Calero MR, et al. Presacral and intrathoracic extramedullary hematopoiesis in a patient with β thalassemia minor. Clin Respir J . 2016 May 5(13)
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Published
16-07-2018
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Patil PR, Rajpurkar SD, Sisodia SM, Patil AA, Ahuja S. Spinal Cord Compression due to Extra Medullary Hematopoiesis in a Case Of Thalassemia Minor: A Rare Case Report. Ann of Pathol and Lab Med [Internet]. 2018 Jul. 16 [cited 2024 Dec. 27];5(7):C91-95. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/1745
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Copyright (c) 2018 Purwa Rangrao Patil, Samruddhi Dilip Rajpurkar, Shantilal M Sisodia, Ajinky Ashok Patil, Sanjana Ahuja
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