Clinical Impact and Emerging Multi Drug Resistance of Acinetobacter Baumannii and Pseudomonas Aeruginosa Isolates
DOI:
https://doi.org/10.21276/apalm.1774Keywords:
A. baumannii, P.aeruginosa, Multi drug resistance, Clinical impactAbstract
Background: Acinetobacter and Pseudomonas are the two most important member of the Non fermenter group. They cause serious life threatening infections. They are mainly nosocomial causing infection in deprived immunity. Multi drug resistance is the major problem which may be intrinsic, or extrinsic.
Methods: It was a prospective study done in tertiary care hospital, Surat. All clinical samples were included. Processing of samples, identification of isolates and antibiotic susceptibility were done using standard guidelines. Clinical correlation of the patients was done.
Result: Total 151 samples showed growth of Acinetobacter and Pseudomonas. A. Baumannii was the most common isolated followed by P. aeruginosa. Only Polymyxins showed complete sensitivity. Most of the isolates were from surgical and orthopedic wards with trauma as predominant infectious cause. Monomicrobial infections and male preponderance were observed. Most of the patients got discharged within 10 days of admission. Clinical outcome showed 72 % of discharge rate followed by death.
Conclusion: The only group having complete sensitivity towards organisms was the Polymyxin group. The most common cause being trauma, strict infection control practices with emphasis on hand hygiene should be followed to prevent emergence of pan drug resistant bacteria.
References
2. Rani PU, Vijayalakshmi P. Epidemiological Pattern of Non-fermenting Metallo Beta Lactamase Producing Bacterial Pathogens Isolated from Clinical Specimens in a Tertiary Care Hospital in Kakinada , India. 2017;18(3):1–6.
3. Wadhwa R, Sharma Y, Upadhyay RP, Bala K. Nosocomial infection by non-fermenting gram negative bacilli in tertiary care hospital: Screening and cure. Int J Pharm Pharm Sci. 2016;8(3):274–7.
4. The Clinical and Laboratory Standards Institute. M100S Performance Standards for Antimicrobial Susceptibility Testing. 2017.
5. Sinha M, Srinivasa H, Macaden R. Antibiotic resistance profile & extended spectrum beta-lactamase (ESBL) production in Acinetobacter species. Indian J Med Res. 2007;126(1):63–7.
6. Rit K, Nag F, Raj HJ, Maity PK. Prevalence and Susceptibility Profiles of Nonfermentative Gram-negative Bacilli Infection in. Indian J Clin Pract. 2013;24(5):451–5.
7. Shete VB, Ghadage DP, Muley VA, Bhore A V. Acinetobacter Septicemia in Neonates Admitted to Intensive Care Units. 2009;1(2) :73–6.
8. Kamalraj M, Sivashankari S, Thamarai S, Apurba S. Non fermenting gram negative bacilli from various clinical samples in a tertiary care hospital. 2015;6(2):5230–5.
9. Taneja N, Maharwal S, Sharma M. Imipenem Resistance in Nonfermenters Causing Nosocomial Urinary Tract Infections. Indian J Med Sci. 2003;57(7):294–9.
10. Padmavathy M, Malini J, Naveneeth B V. Prevalence of non-fermenting Gram-negative bacilli and their in vitro susceptibility pattern at a tertiary care teaching hospital. 2014;41(3):162–6.
11. Thipperudraswamy T, Sudhindra.K, Shobha Nadigar, Mahesh Kumar. Prevalence of non-fermenting gram negative bacilli from clinical isolates and their antibiogram. 2014;3(2):55–61.
12. Vishwanath S, Munim F, Chawla K. Nonfermenting gram-negative bacilli other than pseudomonas aeruginosa and acinetobacter spp. causing respiratory tract infections in a tertiary care center. J Glob Infect Dis. 2013;5(4):144-8.
13. Cunha Daniel Ferreira da, Barbosa Ana Augusta Sousa, Manfrin Alessandra, Tiveron Fabiana Sucupira, Cunha Selma Freire de Carvalho da. Sodium serum levels in hypoalbuminemic adults at general medical wards. Rev. Hosp. Clin. 1999; 54(2): 39-42.
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