Adenocarcinoma of Ampulla of Vater Presented as Recurrent Jaundice

Authors

  • Sunil Vitthalrao Jagtap Dept of Pathology, KIMS, University, Karad. Maharashtra, India
  • Cyrus Dhara Jokhi Dept of Pathology, KIMS, University, Karad. Maharashtra, India
  • Digvijay Patil Dept of Pathology, KIMS, University, Karad. Maharashtra, India
  • Swati S Jagtap Dept of Pathology, KIMS, University, Karad. Maharashtra, India

DOI:

https://doi.org/10.21276/apalm.1809

Keywords:

Ampullary carcinoma, Pancreatico-biliary tract neoplasm, histopathology

Abstract

Background Ampullary carcinoma are relatively uncommon neoplasm which approximately seen in  0.2% of gastrointestinal carcinomas. Clinically these patient generally present at an earlier stage of the disease. As their strategic location may cause early biliary obstruction.

Case history A 70 year old male patient was presented with history of pain in abdomen, anorexia and repeated history of  jaundice. On ultrasonography and  CT scan abdomen-pelvis showed proliferative growth at periampullary area suggestive of ampullary malignancy.  Associated cholelithiasis was noted. Patient underwent surgical treatment of pancreaticoduodenectomy with cholecystectomy. On histopathology revealed moderately differentiated intestinal type of adenocarcinoma of ampulla of Vater, Grade II.

Conclusion  We are presenting this uncommon neoplasm for its rarity, recently distinguished subtype on histopathology, clinical behavior and radiological findings.

Author Biographies

Sunil Vitthalrao Jagtap, Dept of Pathology, KIMS, University, Karad. Maharashtra, India

Professor, Dept of Pathology,  KIMS, University, Karad. Maharashtra, India

Cyrus Dhara Jokhi, Dept of Pathology, KIMS, University, Karad. Maharashtra, India

Dept of Pathology,  KIMS, University, Karad. Maharashtra, India

Digvijay Patil, Dept of Pathology, KIMS, University, Karad. Maharashtra, India

Dept of Pathology,  KIMS, University, Karad. Maharashtra, India

Swati S Jagtap, Dept of Pathology, KIMS, University, Karad. Maharashtra, India

Physiology, Asso professor

References

Benhamiche AM, Jouve JL, Manfredi S, Prost P, Isambert N, Faivre J .Cancer of the ampulla of Vater: results of a 20-year population-based study, Eur J Gastroenterol Hepatol. 2000 Jan;12(1):75-9.

Kim RD, Kundhal PS, McGilvray ID, Cattral MS, Taylor B, Langer B, Grant DR, Zogopoulos G, Shah SA, Greig PD, et al. Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg. 2006;202:112–119.

Zhou H, Schaefer N, Wolff M, et al. Carcinoma of the ampulla of Vater : comparative histologic/immunohistochemical classification and follow-up. Am J Surg Pathol 2004;28:875-882.

Kimura W, Futakawa N, Zhao B. Neoplastic diseases of the ampulla of Vater. J Hepatobiliary Pancreat Surg 2004;11:223-231.

Costi R, Carvana P, Sarli I, et al. Ampullary adenocarcinoma in neurofibromatosis type I. Case report and literature review. Mod Pathol 2001;14:1169-74.

Wagner PI, Chen YT, Yantiss RK. Immunohistochemical and molecular features of sporadic and FAP-associated duodenal adenomas of ampullary and nonampullary mucosa. Am J Surg Pathol 2008;32:1338-1395.

Gardiner GW, Lojrie G, Keith R. Hepatoid adenocarcinoma of the papilla of Vater. Histopathology 1992;20:541-544.

Carter JT, Grenert JP, Rubenstein L. Tumors of the ampulla of Vater, histological classification and predictor of survival. J Am Coll Surg 2008,207(2):210-8.

Berberat PO, Kunzli BM, Gulbinas A, et al. An audit of outcomes of a series of periampullary carcinoma. Eur J Surg Oncol 2009;35:187-91.

Howe JR, Klimstra DS, Moccia RD, et al. Factors predictive of survival in ampullary carcinoma. Ann Surg 1998;228:87-94.

Kim WS, Choi DW, Choi SH, et al. Clinical significance of pathologic subtype in curatively resected ampulla of Vater. J Surg Oncol 2012;105(3):266-72.

Downloads

Published

17-06-2018

How to Cite

1.
Jagtap SV, Jokhi CD, Patil D, Jagtap SS. Adenocarcinoma of Ampulla of Vater Presented as Recurrent Jaundice. Ann of Pathol and Lab Med [Internet]. 2018 Jun. 17 [cited 2024 Nov. 23];5(6):C82-84. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/1809

Issue

Section

Case Report