Primary pure large cell neuroendocrine carcinoma of ovary: An extremely rare entity

Authors

  • Poonam Bhaker Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 INDIA
  • Pranab Dey PGIMER, Chandigarh
  • Radhika Srinivasan PGIMER, Chandigarh
  • Subhash Chandra Saha PGIMER, Chandigarh

Keywords:

Immunohistochemistry, Neuroendocrine Carcinoma, Ovary, Primary

Abstract

Primary large cell neuroendocrine carcinoma of ovary is an uncommon neoplasm with an aggressive biological behaviour. These carcinomas usually occur in association with epithelial-sex cord tumours; pure form being a rarity which can pose a diagnostic difficulty. A 42 year old female presented with a large abdominal mass and pain.  Computed tomography revealed a heterogeneously enhancing solid left ovarian mass. Differential diagnoses on histopathology included large cell neuroendocrine carcinoma, carcinoid tumour, hepatoid carcinoma and malignant steroid cell tumour, not otherwise specified (NOS). Positive neuroendocrine markers including CD56, chromogranin, and NSE facilitated a correct diagnosis of large cell neuroendocrine carcinoma. Primary ovarian large cell neuroendocrine carcinomas are under-recognized aggressive tumours and must be considered as a differential in undifferentiated ovarian tumours. Histologic features and a panel of immunohistochemical stains should lead to the correct diagnosis.

Author Biographies

Pranab Dey, PGIMER, Chandigarh

Professor

Deptt of cytology and gynaecologic pathology

Radhika Srinivasan, PGIMER, Chandigarh

Professor

Deptt of cytology and gynaecologic pathology

Subhash Chandra Saha, PGIMER, Chandigarh

Additional Professor, Department of Gynecology and Obstetrics,

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Published

28-01-2014

How to Cite

1.
Bhaker P, Dey P, Srinivasan R, Saha SC. Primary pure large cell neuroendocrine carcinoma of ovary: An extremely rare entity. Ann of Pathol and Lab Med [Internet]. 2014 Jan. 28 [cited 2024 Nov. 5];2(1):C1-C4. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/184

Issue

Vol. 2 No. 1 (2015)

Section

Case Report

License

Copyright (c) 2015 Poonam Bhaker, Pranab Dey, Radhika Srinivasan, Subhash Chandra Saha

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