Histopathological Study of Infectious Granulomatous Skin Lesions
Keywords:
Granuloma, histopathology, leprosy, tuberculosis.
Abstract
Background: Granulomas are the commonest lesions that the pathologists come across in routine practice. Granulomatous inflammation is a distinctive pattern of chronic inflammation that is encountered in a number of infectious and non-infectious conditions. A definitive diagnosis made by demonstration of the etiological agent is essential, which will bear an impact on patient management and outcome. Methods: This is a retrospective study considering the cases of 2 years. The cases diagnosed as infectious granulomatous skin lesions by clinical presentation, histopathological study of skin biopsies of such patients attending our hospital since July 2010 to July 2012 were included in the study. Clinical history and relevant data were obtained from respective requisition forms of biopsies received. Results: The study includes 67 cases. A male predominance was noted with 47(70.14%) cases while females constituted 20(29.85%) cases .The study shows that 80% of cases are distributed between 21 to 50 yrs of age while the prevalence of infectious granulomatous dermatoses is highest in the age group of 21-30 yrs. Among the different types of infectious granulomatous dermatoses, leprosy contributed to the major etiology, followed by tuberculosis of skin, leishmaniasis and actinomycosis. Conclusion: Clinical data with the laboratory workup and special stains together are needed for the definitive diagnosis and management of patients with granulomatous lesions. Cooperation between clinician and pathologist is more important in the field of skin disease than in almost any other field if the patient is to derive the greatest benefit from the biopsy.References
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13. Arfan Ul B, Shehzad A, Amer E, Tariq M. Comparison of Various Cytodiagnostic Tests in Rapid Diagnosisof Cutaneous Of Leishmaniasis. Journal of Pakistan Association of Dermatologists.2010; 20: 63-9.
14. Sebastian L, Klaus S, Eckart H. Bacterial Diseases, Protozoan Diseases & Parasitic Infestations in Lever’s Histopathology Of Skin 10th Edition, New Delhi; Lippincott Willimas & Wilkins .2009;550-572 &621-4.
15. Nayak SV, Shivrudrappa AS, Mukamil AS. Role of fluorescent microscopy in detecting Mycobacterium leprae in tissue sections. Annals of diagnostic pathology 2003 April; 7(2): 78-81.
2. Kumar V, Abbas AK, Fausto N, Aster JC .Acute And Chronic Inflammation. In Robbins And Cotran’s . Pathologic Basis of Disease. 8th Edition: New Delhi; Elsevier India. 2010: 73-4.
3. Permi H, Shetty JK. , Shetty KP , Teerthanath S, Mathias M , Kumar YS , Prasad H.L. , Chandrika A Histopathological Study Of Granulomatous Inflammation. Nitte University Journal of Health Science.2012; 2(1): 15-9.
4. Zaim MT, Bordell RT, Pokorney Dr. Non Neoplastic Inflammatory Dermatoses: A Clinicopathologic Correlative Approach. Mod Pathology.1990;3:381-414.
5. Amanjit B, Harsh M, GP Dhami. Infectious Granulomatous Dermatitis. Indian Journal of Dermatology. 2006;51(3):217-20.
6. Weedon D. The Granulomatous Reaction Pattern In: Skin Pathology.2nd Edition; New York: Churchill Livingstone; 2000: 94-213.
7. Gautam K, Pai RR, S Bhat. Granulomatous Lesions of Skin. Journal of Pathology of Nepal 2011; 1(2):81-86.
8. Lockwood DN, Nicholas P, Smith WC, Das L, Barkataki P , Van BW, Suneetha S. Comparing The Clinical And Histological Diagnosis Of Leprosy And Leprosy Reactions In Infir Cohort Of Indian Patients With Multibacillary Leprosy.Plos Neglected Tropical Diseases ,6(6),E1702.
9. Mohammed EL K, Ibrahin M, Bayoumi E, Hussein H El N, Clinicopathological Features & The Practice of Diagnosing Infectious Cutaneous Granulomas In Egypt. International Journal of Infectious Diseases. 2011; 15: 620-6.
10. Rubina Q, Riyaz A S, Anwar Ul H. Chronic Granulomatous Inflammatory Disorders of Skin At A Tertiary Care Hospital In Islamabad. International Journal of Pathology; 2004; 2(1): 31-4.
11. Wayne Gr, Eduward C & Philip M. Infectious Diseases of The Skin in Pathology Of Skin With Clinical Correlations 3rd Ed Vol. 1elsievier Mosby. 2005: 837-991.
12. T J Stephenson Inflammation: General & Systemic Pathology 5th Edition;Edinburgh: Churchill Livingstone.2009: 216-19.
13. Arfan Ul B, Shehzad A, Amer E, Tariq M. Comparison of Various Cytodiagnostic Tests in Rapid Diagnosisof Cutaneous Of Leishmaniasis. Journal of Pakistan Association of Dermatologists.2010; 20: 63-9.
14. Sebastian L, Klaus S, Eckart H. Bacterial Diseases, Protozoan Diseases & Parasitic Infestations in Lever’s Histopathology Of Skin 10th Edition, New Delhi; Lippincott Willimas & Wilkins .2009;550-572 &621-4.
15. Nayak SV, Shivrudrappa AS, Mukamil AS. Role of fluorescent microscopy in detecting Mycobacterium leprae in tissue sections. Annals of diagnostic pathology 2003 April; 7(2): 78-81.
Published
20-07-2018
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