Expression of Estrogen and Progesterone Receptor Status in Breast Carcinoma Using Quick Score
A Study at a Tertiary Care Centre in Kerala
DOI:
https://doi.org/10.21276/apalm.2001Keywords:
Breast cancer, Immunohistochemistry, Estrogen receptor, Progesterone receptor, Bloom Richardson Grading, Quick scoreAbstract
Background : Breast carcinoma is the most common malignant tumour and the leading cause of carcinoma death in women. The hormone receptor status is important nowadays due to its prognostic and therapeutic significance. The objective of this study was to correlate estrogen (ER) and progesterone receptor (PR) status with clinicopathological parameters like age, lymphnode status, size of the tumour and tumour grade of breast carcinoma.
Methods : This study was conducted in the Department of Pathology, Government Medical College, Thrissur from January 2012- June 2013. 100 mastectomy specimens were received and analysed for both histological grading and immunohistochemically by quick score for ER and PR markers.
Results : Majority of the cases were between 50-60 years of age with invasive ductal carcinoma grade 2. ER, PR positivity in this study was 67% and 62% respectively with both receptors positive for 61% of cases. In this study 55% showed no axillary lymphnode involvement and 45% showed lymphnode involvement with majority cases had size between 2 and 5 cm.
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