Clinicopathological Significance Of Human Epidermal Growth Factor Receptor- 2 (HER-2/Neu) Over-Expression In Gastric And Oesophageal Carcinomas Of Upper Gastrointestinal Biopsies
DOI:
https://doi.org/10.21276/apalm.2045Keywords:
Adenocarcinoma, endoscopic biopsy, HER-2/neu, immunohistochemistry.Abstract
INTRODUCTION: HER-2/neu plays a key role in the pathogenesis of gastric and oesophageal carcinomas and it's over expression has been documented in 6.8—34% of gastric carcinomas and 10-12.1% of oesophageal adenocarcinoma. Detecting the HER-2/neu status is a prerequisite for monoclonal antibody therapy. In this study, immunohistochemistry was used to detect HER-2/neu over- expression in gastric and oesophageal carcinomas.
OBJECTIVE: To associate HER-2/neu over-expression with age, sex, type and grade of gastric and esophageal carcinomas in upper gastrointestinal (UGI) endoscopic biopsies.
METHODS: HER-2/neu expression was investigated by immunohistochemistry on esophageal and gastric carcinomas of UGI endoscopic biopsies received at our institution. Association between the expression of HER-2/neu and clinico-pathological parameters was statistically analysed.
RESULTS: The association was not statistically significant between age, sex and grade of the tumour with HER-2/neu overexpression. HER-2/neu overexpression was seen in 14.2% of gastric adenocarcinomas, 20% of esophageal adenocarcinomas and 4% of esophageal squamous cell carcinomas. Predominantly, intestinal type (9.5%) of gastric carcinoma showed HER-2neu over-expression followed by diffuse type (2.3%) and mixed type (2.3%).
CONCLUSION: In view of increasing trend of UGI tract malignancies and associated poor survival of advanced carcinomas, assessing HER-2/neu over-expression in gastric and esophageal carcinomas is helpful to decide the utility of adjuvant targeted chemotherapy.
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