Diagnostic utility of immunohistochemical expression of HE4 in Epithelial Ovarian Neoplasm

Authors

  • Begum Afrin Nahar IPGME & R, Kolkata, India
  • Rama Saha IPGME & R, Kolkata
  • Chhanda Das IPGME & R, Kolkata
  • Gourishankar Kamilya Department of Obstetrics and Gynaecology

DOI:

https://doi.org/10.21276/apalm.2444

Keywords:

Biomarker, Epithelial ovarian neoplasm, HE4

Abstract

Background: Mortality in case of ovarian malignancy is high due to late diagnosis. Early and accurate diagnosis can improve the case specific management. HE4 (human epididymis protein 4) which is proved to be overexpressed in the ovarian cancer cells, is considered a new biomarker for ovarian cancer diagnosis. Aims and objectives: The study was undertaken to evaluate the immunohistochemical expression of HE4 in various epithelial ovarian neoplasm.

Material and Methods: It was a cross sectional, prospective, single institution based study, conducted in the department of Pathology in collaboration with the department of Gynecology and Obstetrics, from December 2016 to January 2019 in our institution. A total 71 cases were selected for this study.

Results: Serous tumour was the most common epithelial tumour followed by mucinous tumour. Highest percentage of expression of HE4 was seen in high grade serous cancer and malignant endometrioid tumour. Benign serous and mucinous tumour shows negative expression mostly. We found statistically significant correlation between HE4 expression and different types of epithelial ovarian tumours (p=0.000).

Conclusions: HE4 was highly expressed in malignant ovarian tumour especially serous and endometrioid carcinoma and can be used as an important biomarker for malignant ovarian neoplasm. Expression in high grade ovarian serous cancer supports its prognostic value also.

Author Biographies

Begum Afrin Nahar, IPGME & R, Kolkata, India

Dept of Pathology

Rama Saha, IPGME & R, Kolkata

Dept of Pathology

Chhanda Das, IPGME & R, Kolkata

Dept of Pathology

Gourishankar Kamilya, Department of Obstetrics and Gynaecology

Dept of Pathology

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Published

23-11-2019

How to Cite

1.
Nahar BA, Saha R, Das C, Kamilya G. Diagnostic utility of immunohistochemical expression of HE4 in Epithelial Ovarian Neoplasm. Ann of Pathol and Lab Med [Internet]. 2019 Nov. 23 [cited 2024 Oct. 30];6(11):A567-571. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2444

Issue

Vol. 6 No. 11 (2019)

Section

Original Article

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Copyright (c) 2019 Begum Afrin Nahar, Rama Saha, Chhanda Das, Gourishankar Kamilya

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