Seroprevalence of Syphilis Infection among Apparently Clinically Healthy Blood Donors in Northern Mid - Karnataka
Keywords:
Seroprevalence, Replacement donors, Voluntary donors
Abstract
Background: Blood transfusion is one of the important modalities of treatment in hospitals these days. Transfusion transmissible infections (TTI) are one of the important complications of blood transfusion. Objective: To study the seroprevalence of syphilis infection among healthy blood donors in our region Materials and methods: This is a retrospective study done over a period of 3 years from August 2015 to July 2018 in two blood banks of Gadag i.e. Gadag Institute of Medical Sciences (GIMS) blood bank and Indian Medical Association (IMA) blood bank. A total of 20,144 blood donors were included in the study. It included both voluntary donors and replacement donors. Donors were screened using donor questionnaire form followed by general physical examination for medical and surgical illness. Eligible blood donors donated blood and their blood samples were subjected to a test that detected the presence of non treponemal antibodies by using rapid plasma reagin (RPR) test kit. Result: In the present study, the total number of donors is 20,144. Out of this, 19,676 (97.67%) were males and 468 (2.33%) were females. Total number of seropositive cases of syphilis was 5. The overall seroprevalence was 0.023%. All the seropositive cases were males. The prevalence of seropositive cases among voluntary donors was 0% and among replacement donors was 0.14% Conclusion: Seroprevalence of syphilis in the region of Gadag is 0.023%.References
1. Bagiyalakshmi V, Gopal R, Elangovan RS. Seroprevalence of hepatitis B virus infection among volunatary blood donors at a tertiary care hospital blood bank-Tiruchirapalli. Int J Sci Stud. 2017;4(10):105-8
2. Mcpherson RA, Pincus MR (Eds). Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd edition. New Delhi: Reed Elsevier India Private Limited; 2012
3. Khageshan AP, Kulkarni KR, Baragundi MC. Seroreactivity of syphilis among blood donors of a blood bank. Annals of Pathology and Laboratory Medicine. 2016;3(1):41-4
4. Morshed MG, Singh AE. Recent trends in the serologic diagnosis of Syphilis. Clinical and Vaccine Immunology. 2015;22(2): 137-47
5. Arora D, Arora B, Kheterpal A. Seroprevlence of HIV, HCV and syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol. 2010;53(2):308-9
6. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2001;44(4):409-12
7. Srikrishna A, Sitalakshmi S, Damodhar P. How safe are our safe donors? Indian J Pathol Microbiol. 1999;42:411-6
8. Sonawane BR, Birare SD, Kulkarni PV. Prevalence of seroreactivity among blood donors in rural population. Indian J Med Sci. 2003;57:405-7
9. Singh B, Verma M, Kotru M, Verma K, Batra M. Prevalence of HIV and VDRL seropositivity in blood donors of Delhi. Indian J Med Res. 2005;122:234-6
10. Bhattacharya P, Chandra PK, Datta S, Banerjee Arup, Chakraborty S, Rajendran K, et al. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007;13(27):3730-3
11. Pallavi P, Ganesh CK, Jayashree K, Manjunath CV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a University hospital blood bank: A 5 year study. Indian J Hematol Blood Transfus. 2011;27(1):1-6
12. Kaur G, Basu S, Kaur R, Kaur P, Garg S. Patterns of infections among blood donors in a tertiary care center: A retrospective study. Natl Med J India . 2010;23(3):147-9
13. Chaudhary V, Agarwal VK, Sexena KS, Upadhyay D, Singh A, Singh SP. Seroprevalence of common transfusion transmissible infections among blood donors in Western Uttar Pradesh, India. Int J Med Sci Public Health. 2014;3(11):1381-4
14. Rompolo AM, Cannon RO, Quinn TC, Hook EW. Association of biologic false-positive reactions for syphilis with human immunodefiency virus infection. J Infect Dis. 1992;165(6):1124-6
2. Mcpherson RA, Pincus MR (Eds). Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd edition. New Delhi: Reed Elsevier India Private Limited; 2012
3. Khageshan AP, Kulkarni KR, Baragundi MC. Seroreactivity of syphilis among blood donors of a blood bank. Annals of Pathology and Laboratory Medicine. 2016;3(1):41-4
4. Morshed MG, Singh AE. Recent trends in the serologic diagnosis of Syphilis. Clinical and Vaccine Immunology. 2015;22(2): 137-47
5. Arora D, Arora B, Kheterpal A. Seroprevlence of HIV, HCV and syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol. 2010;53(2):308-9
6. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2001;44(4):409-12
7. Srikrishna A, Sitalakshmi S, Damodhar P. How safe are our safe donors? Indian J Pathol Microbiol. 1999;42:411-6
8. Sonawane BR, Birare SD, Kulkarni PV. Prevalence of seroreactivity among blood donors in rural population. Indian J Med Sci. 2003;57:405-7
9. Singh B, Verma M, Kotru M, Verma K, Batra M. Prevalence of HIV and VDRL seropositivity in blood donors of Delhi. Indian J Med Res. 2005;122:234-6
10. Bhattacharya P, Chandra PK, Datta S, Banerjee Arup, Chakraborty S, Rajendran K, et al. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007;13(27):3730-3
11. Pallavi P, Ganesh CK, Jayashree K, Manjunath CV. Seroprevalence and trends in transfusion transmitted infections among blood donors in a University hospital blood bank: A 5 year study. Indian J Hematol Blood Transfus. 2011;27(1):1-6
12. Kaur G, Basu S, Kaur R, Kaur P, Garg S. Patterns of infections among blood donors in a tertiary care center: A retrospective study. Natl Med J India . 2010;23(3):147-9
13. Chaudhary V, Agarwal VK, Sexena KS, Upadhyay D, Singh A, Singh SP. Seroprevalence of common transfusion transmissible infections among blood donors in Western Uttar Pradesh, India. Int J Med Sci Public Health. 2014;3(11):1381-4
14. Rompolo AM, Cannon RO, Quinn TC, Hook EW. Association of biologic false-positive reactions for syphilis with human immunodefiency virus infection. J Infect Dis. 1992;165(6):1124-6
Published
02-08-2019
Issue
Section
Original Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
