Neutrophil to lymphocyte ratio and Platelet to lymphocyte ratio: Novel markers of inflammation in Psoriasis
DOI:
https://doi.org/10.21276/apalm.2546Keywords:
neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, psoriasis, PASIAbstract
Background:
Psoriasis is a systemic, autoimmune chronic inflammatory disease. Novel inflammatory biomarkers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) may help in evaluation of systemic inflammation. Aim of the present study was to evaluate NLR and PLR in patients of psoriasis and to correlate them with psoriasis area severity index (PASI) score.
Methods:
The study was done in a tertiary care hospital. A study was performed with 40 psoriasis patients (study group) and 20 healthy control subjects. Complete hemogram was determined using the 5-part hematology analyser. NLR and PLR values were calculated from the appropriate absolute cell counts. Mann-Whitney U test was applied to compare the data between patients and controls. Pearson correlation was used to find correlation between NLR, PLR and PASI.
Result:
Mean PLR was 121.79 (42.36) for study group and 101.42 (SD 52.28) for the control group. We found that PLR was significantly higher in study group than the control group (p value = 0.041). There was a positive correlation between PASI and PLR (r=0.476, p value 0.002). We found no difference in NLR values between patients and controls as well as no correlation between PASI and NLR in the study group.
Conclusion:
PLR can be used as a biomarker to measure and monitor the disease activity in psoriasis patients at the time of diagnosis and follow up. This can also aid in preventing comorbidities in psoriasis patients.
References
2. Dogra S, Mahajan R. Psoriasis: Epidemiology, clinical features, co-morbidities, and clinical scoring. Indian Dermatol Online J. 2016;7:471-80.
3. Villanova F, Di Meglio P, Nestle FO. Biomarkers in psoriasis and psoriatic arthritis. Ann Rheum Dis. 2013;72 Suppl 2:ii104-10.
4. Kim DS, Shin D, Lee MS, Kim HJ, Kim DY, Kim SM, et al. Assessments of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in Korean patients with psoriasis vulgaris and psoriatic arthritis. J Dermatol. 2016;43:305-10.
5. Paul C, Gourraud PA, Bronsard V, Prey S, Puzenat E, Aractingi S, et al. Evidence-based recommendations to assess psoriasis severity: systematic literature review and expert opinion of a panel of dermatologists. J Eur Acad Dermatol Venereol. 2010;24 Suppl 2:2-9.
6. Uysal S, Yilmaz FM, Karatoprak K, Artuz F, Cumbul NU. The levels of serum pentraxin3, CRP, fetuin-A, and insulin in patients with psoriasis. Eur Rev Med Pharmacol Sci. 2014;18:3453-8.
7. Beygi S, Lajevardi V, Abedini R. C-reactive protein in psoriasis: a review of the literature. J Eur Acad Dermatol Venereol. 2014;28:700-11.
8. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol. 2010;106:470-6.
9. Buyukkaya E, Karakas MF, Karakas E, Akcay AB, Tanboga IH, Kurt M, et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome. Clin Appl Thromb Hemost. 2014;20:159-63.
10. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5:2.
11. Fu H, Qin B, Hu Z, Ma N, Yang M, Wei T, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269-73.
12. Huang W, Huang J, Liu Q, Lin F, He Z, Zeng Z, et al. Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy. Clin Endocrinol (Oxf). 2015;82:229-33.
13. Polat M, Bugdayci G, Kaya H, Oguzman H. Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in Turkish patients with chronic plaque psoriasis. Acta Dermatovenerol Alp Pannonica Adriat. 2017;26:97-100.
14. Asahina A, Kubo N, Umezawa Y, Honda H, Yanaba K, Nakagawa H. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: Response to therapy with biologics. J Dermatol. 2017;44:1112-21.
15. Raghavan V, Radha RKN, Rao RK, Kuberan A. A Correlative Study between Platelet Count, Mean Platelet Volume and Red Cell Distribution Width with the Disease Severity Index in Psoriasis Patients. J Clin Diagn Res. 2017;11:EC13-EC6.
16. Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Mater Sociomed. 2014;26:231-3.
17. Yurtdas M, Yaylali YT, Kaya Y, Ozdemir M, Ozkan I, Aladag N. Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis. Echocardiography. 2014;31:1095-104.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Shakti Kumar Yadav, Santosh Sharma, Sompal Singh, V K Khurana, Namrata Sarin
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
