A Review of Triple Negtive Marker of IHC in Medullary Carcinoma Breast
An Uncommon Substype with Good Prognosis
DOI:
https://doi.org/10.21276/apalm.2620Keywords:
Medullary carcinoma breast, BIRADS II, triple negative IHC markersAbstract
Medullary carcinoma of the breast is an uncommon variant of invasive ductal carcinoma, which constitutes nearly 5% of all breast cancers in men and women. These tumours are often associated with favourable prognosis despite showing aggressive behaviour. In this study a patient presented with history of breast lump aged 48 years in left breast since one year .In mammography it was described as BIRADS II and fine needle aspiration cytology showed suspicious for malignancy .Histopathology report showed medullary carcinoma breast lesion. Immunochemistry was also done for ER , PR and Her-2neu and it showed negative for ER ,PR and HER 2 Neu.
References
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2. Jagtap . S , Saini .N , Jagtap .S , Saini. S . Medullary carcinoma of breast , Case report . International J of health care and biomedical research , Volume 03 , issue 04 , 2015 , pg 55-58
3 N. Sajjan , V. BR , M. Srinivasa . Cytomorphological study of medullary carcinoma breast in comparison to infiltration Ductal carcinoma . Journal of cytology , 2018 , 35, 195-98
4. Tavasolli FA, Devilee P. World health organization classification of tumours, Pathology and genetics of tumours of breast and female genital organs. Lyon: IARC press; 2003.
5. . Saad RS, Silverman JF. Breast. In: Bibbo M, editor. Comprehensive Cytopathology. 2nd ed. Elsiever; 1997. p. 713‑72.
6. Gattuso P, Reddy V, David O, Spitz D, Haber M. Infiltrating carcinoma: Pathological types. In Differential Diagnosis in Surgical Pathology. 2nd ed.US Saunders, Elsevier ; 2010. p. 170-214.
7. Howat A, Coghill S. Malignant breast tumours. In: Winifred G, editor. Diagnostic cytopathology, 3rd ed. US Elsevier US;Churchill Livingstone; 2010. p. 279-302.
8. Marginean F, Rakha AE, Ho BC, Ellis IO, Lee AH. Histological features of medullary carcinoma and prognosis in triple negative basal like carcinomas of the breast. Modern Pathology 2010;23:1357‑63.
9. Kuroda H, Tamaru J, Sakamoto G, Ohnisi K, Itoyama S. Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast. Virchows Arch 2005;446:10‑4.
10. Ridolfi RL, Rosen PP, Port A, Kinne D, Mike V. Medullary carcinoma of the breast: A clinicopathological study with 10 year follow‑up. Cancer 1977;40:1365‑85.
11. Santosh T, Bal AK, Patro MK, Choudhaury A. Medullary Breast Carcinoma: A Case Report and Review of Literature. J Cancer Science There 2015;7: 142‑145.
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Published
01-10-2019
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1.
Sahay S, Bansal A, Singh A. A Review of Triple Negtive Marker of IHC in Medullary Carcinoma Breast: An Uncommon Substype with Good Prognosis. Ann of Pathol and Lab Med [Internet]. 2019 Oct. 1 [cited 2024 Oct. 30];6(9):C100-103. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2620
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Copyright (c) 2019 Swati Sahay, Aarushi Bansal, Aditya Singh
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