Aneurysmal Fibrous Histiocytoma:
A Rare Variant
DOI:
https://doi.org/10.21276/apalm.2626Keywords:
Benign fibrous histiocytoma, Dermatofibroma, Cutaneous Histiocytoma, Aneurysmal VariantAbstract
Aneurysmal fibrous histiocytoma (AFH) is a rare variant of benign fibrous histiocytoma. This tumor accounts for less than 2% of all fibrous histiocytomas, 1.7% of all cutaneous fibrous histiocytoma and it is typically known to occur in the extremities of middle-aged patients.
A 23 year old male presented with slow growing, pigmented, nodular lesion on the left leg for the past 2 years. The swelling was initially non-tender, but there was a sudden increase in size associated with pain for the past 2 months. With a clinical suspicion of malignant melanoma an excision biopsy was performed and further evaluated by histopathology. The skin covered pigment lesion measuring 1.5x0.8x0.5cm showed fibrohistiocytic cellular proliferations containing blood filled spaces lacking endothelium on microscopy. Ancillary testing with bleaching, perls prussion blue reaction demonstrated the pigment as hemosiderin. Subsequently the lesion was negative for CD34 and positive for Factor XIIIA. Based on the histomorphology, ancillary testing and IHC, the diagnosis of Aneurysmal fibrous histiocytoma was made.
Aneurysmal fibrous histiocytoma can be a challenging diagnostic entity due to its close clinical resemblance to melanoma and hemngioma. Although the pathogenesis is unclear, it is believed to be caused by extravasation of erythrocytes from capillaries leading to formation of the cystic blood spaces.
References
2. Chaithanya K CUD. Utility of fine needle aspiration cytology in diagnosing soft tissue tumors- experience in our institution. J Diagnostic Pathol Oncol. 2017;2(4):76–81.
3. Akpinar M, Yigit O, Durna YM, Sekercan O, Havare SB. Aneurysmal Fibrous Histiocytoma in Nasal Vestibule Mucosa. Istanbul Med J. 2015;16(2):80–2.
4. Shin JW, Park HS, Kim BK, Kim YA, Kim MG, Won CH, et al. Aneurysmal benign fibrous histiocytoma with atrophic features. Ann Dermatol. 2009;21(1):42–5.
5. Antony A, Kiran CM, Phansalkar M, Jothi C, Jayakar J. Aneurysmal variant of fibrous histiocytoma- A rare entity known for recurrence. J Clin Diagnostic Res. 2017;11(6):ED08–9.
6. Santa Cruz DJ KMA (“angiomatoidâ€), 1981;47:2053- fibrous histiocytoma of the skin. C, 2061. No Title. 1981;
7. Sheehan KM, Leader MB, Sexton S, Cunningham F, Leen E. Recurrent aneurysmal fibrous histiocytoma. J Clin Pathol. 2004;57(3):312–3.
8. McKenna DB, Kavanagh GM, McLaren KM et al. A fibrous, Acad histiocytoma: an unusual variant of cutaneous fibrous histiocytoma. JE, 1999;12:238–40. DV. No Title.
9. Calonje E FC. No Title. Aneurysmal benign fibrous histiocytoma Clin Anal 40 cases a tumour Freq misdiagnosed as a Vasc neoplasm. 1995;26:323-31.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Sheethal Shanibi T M, Vineetha K V, A M Sahabudheen, Vidyadhar Rao
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
