Cytomorphological Study of Thyroid Nodule and Categorization According to The Bethesda System and Its Histopathological Correlation
DOI:
https://doi.org/10.21276/apalm.2632Keywords:
Bethesda system, Fine needle aspiration cytology, histopathologyAbstract
Background: Among an endocrine disorder, thyroid disorders are most commonly encountered disorder in routine clinical practice. Clinically it is quite difficult to evaluate thyroid lesion and reach clinical diagnosis. FNAC (Fine needle aspiration cytology) of thyroid is commonly performed and most effective tool for diagnosis and management of patient with thyroid nodule. Present study was conducted in department of pathology, government medical college, Surat. Our main aims and objectives are to report thyroid cytology smears by TBSRTC in to various diagnostic categories and to correlate these with histopathological findings.
Material and method: In the present study FNAC was performed on total 250 cases that were presented with thyroid swelling. These cases categorized according to TBSRTC and cytological diagnosis was correlated histopathologically in total 21 cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated.
Results: FNAC was carried out in 250 cases, diagnostic categories includes 5.20% non-diagnostic, 87.60% benign, 2.80% Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance, 2.40% follicular neoplasm or suspicious for follicular neoplasm, 1.60% suspicious for malignancy and 0.40% malignant lesions. Subsequent histopathological correlation was possible in 21 cases. In present study accuracy, sensitivity, specificity, positive predictive value and negative predictive value of FNAC in diagnosis of thyroid were 95%, 85.71%, 100%, 100% and 92.85% respectively.
Conclusion: Standardized categorical Bethesda systems for reporting thyroid FNAC can make results easier to understand and interpret for clinicians and give clear indications for therapeutic action.
References
2. Gharia AA., Agravat AH., Dhruva GA. Thyroid Cytology Evaluation By Bethesda System A Two Year Prospective Study. Int J Res Med. 2016; 5(3); 1-6.
3. Sharma S, Dr. Vanita Kumar, Fatima Q, Dr. Dhaka JP, Choudhary M. Cytological Evaluation of Thyroid Lesion on The Basis Of Bethesda System, IJSRM 2017; 5(3): 5193-58.
4. Leopoid G. K, Myron R. Melamed. Koss diagnostic Cytology and its Histopathologic Bases. 5th Edition, Volume 2, 1148-1185
5. Jayaram G, Orell SR. Thyroid. Orell SR, Sterrett GF. Orell and Sterrett;s Fine Needle Aspiration Cytology 5 th edition, 2012 :118-156.
6. Mehrotra D, Anita A.M., Sainath K. Andola and Patil AG. Thyroid Cytology Evaluation Based on the Bethesda System with Clinico-Morphological Correlation. Annals of Pathology and Laboratory Medicine 2016;3(4):A347-A354
7. Shankar SP, Sundaram. MK, Rajalakshmi.V, SatishSelvakumar. A, BhanumathiGiridharan. The Bethesda System for reporting thyroid cytopathology: A two year retrospective review in a tertiary care hospital. Indian Journal of Pathology and Oncology, January - March 2016;3(1);48-54.
8. Edmund S. Cibas, Syed Z. Ali. The Bethasda system for reporting thyroid cytology. Am J ClinPathol 2009; 132:658-665. DOI: 10.1309/AJCPPHLWMI3JV4LA.
9. Syed Z. Ali. Thyroid Cytopathology: Bethesda and Beyond. ActaCytologica 2011;55:4-12. DOI: 10.1159/000322365
10. Syed Z. Ali, Edmund S. Cibas. The Bethesda system for reporting Thyroid cytopathology. Definitions, Criteria, and Explanatory Notes. 1 st edition, 2010, 1-166
11. Syed Z. Ali, Edmund S. Cibas. The Bethesda system for reporting Thyroid cytopathology. Definitions, Criteria, and Explanatory Notes. 2 nd edition, 2018, 1-230.
12. Bagga PK, Mahajan NC. Fine needle aspiration cytology of thyroid swellings: How useful and accurate is it?. Indian Journal of Cancer | October–December 2010 | Volume 47 | Issue 4
13. Mehra P, Verma AK.Thyroid cytopathology reporting by the Bethesda system: A two-year prospective study in an academic institution. Pathology Research International.2015:1-11.
14. Bukhari MH, Khan AA, Niazi S, Arshad M, Akhtar ZM, et al. (2012) Better Thyroid Cytopathology Reporting System May Increase the Clinical Management and Patients Outcome. J Cytol Histol 3:158.
15. A. N. Haberal, S. Toru, O zen, Z. Aratand B. Bilezikci. Diagnostic pitfalls in the evaluation of ï¬ne needle aspiration cytology of the thyroid: correlation with histopathology in 260 cases. Cytopathology 2009, 20, 103–108 2008 The Authors Journal compilation 2008 Blackwell Publishing Ltd.
16. Muratli A, Erdogan N, Sevim S, Unal I, Akyuz S. Diagnostic efficacy and importance of fine-needle aspiration cytology of thyroid nodules. J Cytol 2014;31:73-8.
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