Study to Correlate Histopathological Spectrum of Gastrointestinal Malignant Neoplasm with Demographic Profile of The Patients
DOI:
https://doi.org/10.21276/apalm.2705Keywords:
Epithelial, Mesenchymal, Lymphoma, Neuroendocrine tumours, GISTAbstract
Background: To study occurrence, age and sex distribution, to evaluate and to correlate the various histopathological features of surgical specimens of gastrointestinal tract tumours received at pathology department of GMERS medical college, Gandhinagar (Gujarat, India).
Methods: A histopathological study of gastrointestinal tract tumours of 64 cases was carried out on surgical specimens at GMERS medical college, Gandhinagar from January-2018 to May-2019. Specimens were received in 10% formalin. After proper fixation and grossing of the specimens tissue processing was carried out. Blocks were made, sections were cut and stained with Harris Haematoxylin and Eosin stain and observed microscopically.
Result: From the total of 64 cases: 42 Males and 22 Females were affected with peak occurrence in their sixth decade having anatomical distribution in oesophagus 07(10.93%), stomach 09(14.06%), small intestine 12(18.75%), appendix 01(01.56%), colon and rectum 34(53.12%) and anal canal 01(01.56%). Histological types diagnosed were- epithelial 53(82.81%), mesenchymal 06(09.30%), lymphoma 04(06.27%) and neuroendocrine tumor 01(01.56%).
Conclusion: The occurrence of gastrointestinal tumours was highest in the colon and rectum accounting for 53.12% of cases with most common variety being epithelial. The peak age distribution was in the sixth decade. Male to female ratio was 1.9:1. As Gastrointestinal tumours show a wide variation in the morphology, histopathological examination is must for the diagnosis and typing of these tumours.
References
2. Worldwide cancer data – Global cancer statistics for the most common cancers (2018). Retrieved from https://www.wcrf.org/dietandcancer/cancer-trends/worldwide-cancer-data.
3. Mohammad A, Makaju R. Retrospective histopathological analysis of various neoplasms of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching Hospital (KUTH). Nepal, Kathamandu University Medical Journal 2005; 4: 474-478.
4. Assem O. et al. Primary gastrointestinal cancers in the Western Region of Saud Arabia. Saudi Medical Journal 2000; 21 (8): 730-734.
5. Patel MM, Gamit B, Patel PR. Analysis of gastrointestinal malignancy: A Five Years study. National Journal of Community Medicine 2012;3(3):555-557.
6. Prabhakar BR, Prabhakar H, Tung BS. Gastrointestinal malignant tumours in Amritsar (Punjab). Indian J Surg 1981; 43: 343-5.
7. Mohammad A, Makaju R. Retrospective histopathological analysis of various neoplasms of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching Hospital (KUTH), Dhulikhel, Nepal. Kathmandu. Univ Med J (KUMJ) 2006; 4:474-8. 6. Jamal S, Mamoon N, Mushtaq S, Luqman M. Anal
8. Shahid J, Nadira M, Sajid M, Muhammad L, Analysis of Gastrointestinal malignancy at Armed Forces Institute of Pathology(AFIP), Rawalpindi, Pakistan. Asian pacific journal of cancer prevention 2005; 6:497-500.
9. Leena Devi KK, Suvarna N. Patterns of Gastrointestinal tumours in North Kerala. Indian Journal of Cancer 1980; 17 : 159-163.
10. Jamal S, Mamoon N, Mushtaq S, Luqman M. Analysis of gastrointestinal malignancies at the Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan. Asian Pac J Cancer Prev 2005;6:497-500.
11. Thomas RM, Sobin LH. Gastrointestinal cancer. Cancer 1995; 75:154-70
12. F. B. Abdul Kareem et al. Malignant Gastrointestinal Tumours in western Nigeria: A Histopathologic analysis of 713 cases. West African Journal of Medicine 2009; 8:173-176.
13. Devi KR, Suvarna N. Pattern of gastrointestinal tumours in North Kerala. Indian J Cancer 1980;17:159-63.
14. Lavanaya M, Sreelatha R. Histopathological Study of Tumours of stomach and Intestines. Rajiv Gandhi University of Health sciences, Karnataka, Bangalore; April 2010.
15. Zhou ZW, Wan DS, Chen G, Chen YB, Pan ZZ. Primary malignant tumor of the small intestine. World J gastroenterol1999; 5:273-6.
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