Ano-rectal Melanoma: A Rare Case Report
DOI:
https://doi.org/10.21276/apalm.2789Keywords:
anorectal melanoma, immunohistochemistry, biopsyAbstract
Ano-rectal melanoma is extremely rare and has dismal prognosis when compared to cutaneous melanomas. It presents as ano-rectal mass and patients usually complain of passing blood in stools. Being, a highly aggressive neoplasm, widespread metastasis is common, which can be seen even at the time of diagnosis. Here, we present a case report of ano-rectal melanoma in a 40-year old male, who presented with complaints of anal growth since one month. Initially, a clinical diagnosis of rectal carcinoma was suspected. However, biopsy of the growth showed histomorphological features of melanoma, which were confirmed on immunohistochemistry.
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2. Reid A, Dettrick A, Oakenful C, Lambrianides AL. Primary rectal melanoma. JCSR 2011;11:2.
3. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998; 83:1664-1678.
4. Zhang S, Gao F, Wan D. Effect of misdiagnosis on the prognosis of anorectal malignant melanoma. J Cancer Res Clin Oncol 2010; 136:1401–1405.
5. Dominiak NR, Wick M, Smith T. Mucosal melanomas: Site-specific information, comparisons with cutaneous tumors, and differential diagnosis. Sem Diag Path 2016; 33: 191-7.
6. Correia M, Amonkar D, Ramani A, Desousa R. Anal melanoma-a case report and review of literature. Internet J Surg. 2009;19:13.
7. Morson BC, Volkstadt H. Malignant melanoma of the anal canal. J Clin Path 1963; 16:126.
8. Postow MA, Hamid O, Carvajal RD. Mucosal Melanoma: Pathogenesis, Clinical Behavior, and Management. Curr Oncol Rep (2012) 14:441–448.
9. Thibault C, Sagar P, Nivatrongs S, Ilstrup DM, Wolff BE.Anorectal melanoma--an incurable disease? Dis Colon Rectum. 1997; 40: 661-668.
10. Singer M, Mutch MG. Anal melanoma. Clin Colon Rectal Surg. 2006;19:78–87.
11. Chute DJ, Cousar JB, Mills SE. Anorectal malignant melanoma: morphologic and immunohistochemical features. Am J Clin Pathol. 2006;126:93–100Hillenbrand A, Barth TF, Henne-Bruns D, Formentini A. Anorectal amelanotic melanoma. Colorectal Dis. 2008;10:612–615.
12. Banerjee SS, Harris M. Morphological and immunophenotypic variations in malignant melanoma. Histopathology. 2000;36:387–402.
13. Hillenbrand A, Barth TF, Henne-Bruns D, Formentini A: Anorectal amelanotic melanoma. Colorectal Dis 2008;10:612–615.
14. Gatter KC, Ralfkiaer E, Skinner J, et al. An immunocytochemical study of malignant melanoma and its differential diagnosis from other malignant tumors. J Clin Pathol. 1985;38:1353–1357.
15. Olinici CD, Muntean IL, Resiga LI, CriÅŸan DO. Anorectal melanoma. Case report and review of the literature. Rom J Morphol Embryol. 2007;48(3):299-302.
16. Negbenebor NA, Edward Feller MD. A rare case of amelanotic anorectal melanoma. Rhode Island Medical Journal. 2017 Sep 1;100(9):31.
17. Patrick RJ, Fenske NA, Messina JL. Primary Mucosal Melano¬ma. J Am Acad Derm 2007; 56 (5): 828-34
18. Ben-Izhak O., Bar-Chana M.,Sussman L., Dobiner V., Sandbank J., Cagnano M., Cohen H., Sabo E., Ki67 antigen and PCNA proliferation markers predict survival in anorectal malignant melanoma, Histopathology, 2002, 41(6):519–525.
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Published
30-07-2020
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Khatoon A, Vasantham V, Sharma U, Yadav SK, Kalra R, Jahan A, et al. Ano-rectal Melanoma: A Rare Case Report. Ann of Pathol and Lab Med [Internet]. 2020 Jul. 30 [cited 2024 Nov. 13];7(7):C91-93. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2789
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Copyright (c) 2020 Ayesha Khatoon, Vyshnavi Vasantham, Urvashi Sharma, Shakti Kumar Yadav, Rupinder Kalra, Aarzoo Jahan, Sompal Singh, Namrata Sarin, Sonam Kumar Pruthi
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