A Retrospective Study of Soft Tissue Tumors - Role of Histomorphology in Diagnosis
DOI:
https://doi.org/10.21276/apalm.2855Keywords:
Benign, Malignant, Soft tissue tumors, HistopathologyAbstract
Background: The field of soft tissue tumors is vast and yet to be explored. The diagnosis of these tumors is always challenging for the pathologists. The overlap in the clinical and radiological features makes histopathology very crucial in their identification.
Methods: This is a retrospective study of soft tissue tumors over a period of 18 months from January 2014 to June 2015 conducted in the Department of Pathology. The gross specimens were fixed in 10% formalin and the slides were stained by Hematoxylin and Eosin. Immunohistochemistry was performed wherever necessary.
Result: A total of 235 soft tissue tumors were studied of which benign cases were 225 (95.75%), intermediate 04 (1.70%) and malignant 06 (2.55%). The tumors had a male preponderance, with majority in the third decade, predominantly occurring in the head neck region. Of a total of eleven categories of soft tissue tumors in our study, the adipocytic category was the most common followed by the nerve sheath and vascular tumors.
Conclusion: Molecular diagnosis have started to gain momentum in the field of soft tissue tumors, however histomorphology still remains the gold standard.
References
1. US National Institutes of Health. National Cancer Institute. Dictionary of cancer terms. Retrieved on January. 2007; 19.
2. Jain P, Shrivastava A, Malik R. Clinico-morphological assessment of Soft Tissue Tumors. Sch. J. App. Med. Sci., 2014; 2:886-890.
3. Baste B.D, Swami S.Y, Narhire VV, Dhamecha MP, D’Costa G. A clinico-pathologic study of soft tissue neoplasms: An experience from a rural tertiary care hospital. Ann Trop Med Public Health 2017; 10:348-52.
4. Badwe A, Desai S. Study of Histomorphological pattern of soft tissue tumors in western Maharashtra. Vascular. 2014; 76:25-4.
5. Navya Narayanan. O, Sapna M, Sumangala B. Spectrum of soft tissue tumors in a tertiary care centre - a 5 year study. National Journal of Medical and Dental Research National 2016; 4(2): 83-88.
6. Vahini G. A Clinicopathological Study of Soft Tissue Tumors in Correlation with Immunohistochemistry. IOSR Journal of Dental and Medical Sciences. 2015; 14:31-40.
7. Goldblum JR, Folpe AL, Weiss SW. Benign Fibroblastic/Myofibroblastic Proliferations, Including Superficial Fibromatoses. Enzinger and Weiss’s soft tissue tumors. 6th ed. Philadelphia: Mosby Elsevier. 2014:224-226.
8. Harpal S, Richika, Ramesh K. Histopathological Pattern of Soft Tissue Tumours in 200 Cases. Ann. Int. Med. Den. Res. 2016; 2(6): 6-11
9. Khattak MS, Ahmad F, Khan ZA, Shah H. Histopathological pattern of soft tissues tumors and tumour like lesions in the pathology department of Lady Reading Hospital Peshawar, Pakistan. Journal of Ayub Medical College Abbottabad. Aug 2016; 28(3):514-7.
10. Rao BS, Grandhi B, Shanthi V, Bheemaraju V, Rao NM, Goel A. Clinico Pathological Evaluation of Benign and Malignant Soft Tissue Tumors-2 Years Retrospective Study. JMSCR 2016; 4(6): 10822-10832.
11. Tellapuram V , Ommini S , Veldurthy VS, Paul C, Rao N. Spectrum of soft tissue tumours in rural area of Telangana .International Journal of Research in Health Sciences. 2016; 4(4):81-87.
12. Goyal S, Bala J, Goyal R, Chowdhary K, Narula A. Histopathological spectrum of soft tissue tumor in tertiary care center. International Journal of Clinical and Experimental Physiology. Apr 2015; 2(2):142.
13. Gogi AM, Ramanuj R. Clinicopathological study and management of peripheral soft tissue tumours. Journal of clinical and diagnostic research: JCDR. Nov 2013 ;7(11):2524
14. Agravat AH, Dhruva GA, Parmar SA. Histopathology study of human's soft tissue tumours and tumour like lesions. Journal of cell and Tissue Research. Aug 2010;10(2):2287
15. Ramnani BG, Kumar A, Chandak S, Ranjan A, Patel MK. Clinicopathological profile of benign soft tissue tumours: a study in a tertiary care hospital in Western India. Journal of clinical and diagnostic research: JCDR. Oct 2014;8(10):FC01
16. Chakrabarti PR, Chakrabarti S, Pandit A, Agrawal P, Dosi S, Jain MR. Histopathological study of soft tissue tumors: A three year experience in tertiary care centre. Indian Journal of Pathology and Oncology. Jul 2015;2(3):141-9
17. Deepak MB, Suchitha S, Manjunath GV, Bharadwaj I. Clinico-pathological study of benign soft tissue tumors: a study from tertiary teaching hospital. Tropical Journal of Pathology and Microbiology. Dec 2016 30;2(03)
18. Bharti Devi Thaker D, Gupta A, Thakur K. Pattern of Soft Tissue Tumours in GMC Jammu-A one year Histopathological Study. Sch. J. App. Med. Sci., 2017; 5(6C):2224-2227
19. Rhydholm A, Berg NO. Size, site and clinical incidence of lipoma. Acta Orthop psc and. 1983;54:929-34
20. Lin BT, Weiss LM, Medeiros LJ. Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. The American journal of surgical pathology. Dec 1997;21(12):1443-9
21. Narhire VV, Bagate AN, D’Costa GF. Clinicopathological study of benign soft tissue neoplasms: Experience at rural based tertiary teaching hospital. Indian Journal of Pathology and Oncology. Apr 2016;3(2):268-75
22. Fletcher CDM, Bridge JA, Hogendoorn PC, Mertens F. World Health Organization Classification of tumours of soft tissue and bone. IARC, Lyon; 2013.
23. Umarani MK, Lakra PS, Barathi M. Histopathological spectrum of soft tissue tumors in a teaching hospital. IOSR J Dent Med Sci. Apr 2015;1(14):74-80
24. Anand G, Arora N. Role of Histopathology in Diagnosis of Soft Tissue Swellings. Sch. J. App. Med. Sci., 2017; 5(8B):3056-3059
25. Gabhane SK, Kotwal MN, Bobhate SK. Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian Journal of Pathology and Microbiology. Jan 2009 1;52(1):29
26. Kanth G.V, Krishna RN, Muralikrishna B, Dr.Navin KK, SatyaNarayana V. A Histopathological Study of Soft Tissue Tumors. IOSR Journ of DMS 2015; 14(7): 82-85
27. Gaillard AL, Anastácio VM, Piatto VB, Maniglia JV, Molina FD. A seven-year experience with patients with juvenile nasopharyngeal angiofibroma. Brazilian journal of otorhinolaryngology. Apr 2010; 76(2):245-50.
2. Jain P, Shrivastava A, Malik R. Clinico-morphological assessment of Soft Tissue Tumors. Sch. J. App. Med. Sci., 2014; 2:886-890.
3. Baste B.D, Swami S.Y, Narhire VV, Dhamecha MP, D’Costa G. A clinico-pathologic study of soft tissue neoplasms: An experience from a rural tertiary care hospital. Ann Trop Med Public Health 2017; 10:348-52.
4. Badwe A, Desai S. Study of Histomorphological pattern of soft tissue tumors in western Maharashtra. Vascular. 2014; 76:25-4.
5. Navya Narayanan. O, Sapna M, Sumangala B. Spectrum of soft tissue tumors in a tertiary care centre - a 5 year study. National Journal of Medical and Dental Research National 2016; 4(2): 83-88.
6. Vahini G. A Clinicopathological Study of Soft Tissue Tumors in Correlation with Immunohistochemistry. IOSR Journal of Dental and Medical Sciences. 2015; 14:31-40.
7. Goldblum JR, Folpe AL, Weiss SW. Benign Fibroblastic/Myofibroblastic Proliferations, Including Superficial Fibromatoses. Enzinger and Weiss’s soft tissue tumors. 6th ed. Philadelphia: Mosby Elsevier. 2014:224-226.
8. Harpal S, Richika, Ramesh K. Histopathological Pattern of Soft Tissue Tumours in 200 Cases. Ann. Int. Med. Den. Res. 2016; 2(6): 6-11
9. Khattak MS, Ahmad F, Khan ZA, Shah H. Histopathological pattern of soft tissues tumors and tumour like lesions in the pathology department of Lady Reading Hospital Peshawar, Pakistan. Journal of Ayub Medical College Abbottabad. Aug 2016; 28(3):514-7.
10. Rao BS, Grandhi B, Shanthi V, Bheemaraju V, Rao NM, Goel A. Clinico Pathological Evaluation of Benign and Malignant Soft Tissue Tumors-2 Years Retrospective Study. JMSCR 2016; 4(6): 10822-10832.
11. Tellapuram V , Ommini S , Veldurthy VS, Paul C, Rao N. Spectrum of soft tissue tumours in rural area of Telangana .International Journal of Research in Health Sciences. 2016; 4(4):81-87.
12. Goyal S, Bala J, Goyal R, Chowdhary K, Narula A. Histopathological spectrum of soft tissue tumor in tertiary care center. International Journal of Clinical and Experimental Physiology. Apr 2015; 2(2):142.
13. Gogi AM, Ramanuj R. Clinicopathological study and management of peripheral soft tissue tumours. Journal of clinical and diagnostic research: JCDR. Nov 2013 ;7(11):2524
14. Agravat AH, Dhruva GA, Parmar SA. Histopathology study of human's soft tissue tumours and tumour like lesions. Journal of cell and Tissue Research. Aug 2010;10(2):2287
15. Ramnani BG, Kumar A, Chandak S, Ranjan A, Patel MK. Clinicopathological profile of benign soft tissue tumours: a study in a tertiary care hospital in Western India. Journal of clinical and diagnostic research: JCDR. Oct 2014;8(10):FC01
16. Chakrabarti PR, Chakrabarti S, Pandit A, Agrawal P, Dosi S, Jain MR. Histopathological study of soft tissue tumors: A three year experience in tertiary care centre. Indian Journal of Pathology and Oncology. Jul 2015;2(3):141-9
17. Deepak MB, Suchitha S, Manjunath GV, Bharadwaj I. Clinico-pathological study of benign soft tissue tumors: a study from tertiary teaching hospital. Tropical Journal of Pathology and Microbiology. Dec 2016 30;2(03)
18. Bharti Devi Thaker D, Gupta A, Thakur K. Pattern of Soft Tissue Tumours in GMC Jammu-A one year Histopathological Study. Sch. J. App. Med. Sci., 2017; 5(6C):2224-2227
19. Rhydholm A, Berg NO. Size, site and clinical incidence of lipoma. Acta Orthop psc and. 1983;54:929-34
20. Lin BT, Weiss LM, Medeiros LJ. Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. The American journal of surgical pathology. Dec 1997;21(12):1443-9
21. Narhire VV, Bagate AN, D’Costa GF. Clinicopathological study of benign soft tissue neoplasms: Experience at rural based tertiary teaching hospital. Indian Journal of Pathology and Oncology. Apr 2016;3(2):268-75
22. Fletcher CDM, Bridge JA, Hogendoorn PC, Mertens F. World Health Organization Classification of tumours of soft tissue and bone. IARC, Lyon; 2013.
23. Umarani MK, Lakra PS, Barathi M. Histopathological spectrum of soft tissue tumors in a teaching hospital. IOSR J Dent Med Sci. Apr 2015;1(14):74-80
24. Anand G, Arora N. Role of Histopathology in Diagnosis of Soft Tissue Swellings. Sch. J. App. Med. Sci., 2017; 5(8B):3056-3059
25. Gabhane SK, Kotwal MN, Bobhate SK. Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian Journal of Pathology and Microbiology. Jan 2009 1;52(1):29
26. Kanth G.V, Krishna RN, Muralikrishna B, Dr.Navin KK, SatyaNarayana V. A Histopathological Study of Soft Tissue Tumors. IOSR Journ of DMS 2015; 14(7): 82-85
27. Gaillard AL, Anastácio VM, Piatto VB, Maniglia JV, Molina FD. A seven-year experience with patients with juvenile nasopharyngeal angiofibroma. Brazilian journal of otorhinolaryngology. Apr 2010; 76(2):245-50.
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25-09-2020
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Damani SS, Patil SA, Ansari MH, Baste BD. A Retrospective Study of Soft Tissue Tumors - Role of Histomorphology in Diagnosis. Ann of Pathol and Lab Med [Internet]. 2020 Sep. 25 [cited 2024 Dec. 26];7(9):A465-473. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2855
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Copyright (c) 2020 Sagar Sanjay Damani, Soniya Anant Patil, M H Ansari, Balaji Devrao Baste
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