Clear Cell Morphology in a Salivary Gland Tumor - Clearly a Morphological Dilemma
DOI:
https://doi.org/10.21276/apalm.2927Keywords:
Clear cell tumor, Oncocytoma, Myoepithelioma, Benign tumors, Salivary Gland tumorsAbstract
Primary salivary gland tumors with clear cell morphology comprise an uncommonly encountered subgroup of salivary gland neoplasm. Clear cell morphology is a known feature in both benign and malignant salivary gland tumors. Oncocytomas are uncommon tumors of the salivary gland. They have an abundance of mitochondria, which is manifested as granular eosinophilic cytoplasm by light microscopy with presence of cytoplasmic glycogen. Fixation artifact can impart cytoplasmic clearing and oncocytomas with a predominance of clear cytoplasm are labeled Clear cell oncocytomas. Accurate diagnosis of salivary gland tumors can be challenging because of the many diagnostic entities, extensive morphologic overlap, and the rarity of most tumor types. Here we report a case of Clear cell salivary oncoctyoma which was confirmed by Immunohistochemical markers by excluding morphological differential of Clear cell myoepithelioma.
References
Ellis GL. ‘‘Clear cell’’ oncocytomas of salivary gland. Hum Pathol. 1988;19; 862–867.
Ellis GL. Clear cell neoplasms in salivary glands: clearly a diagnostic challenge.Ann Diagn Pathol. 1998;2:61–78.
Saqi A, Giorgadze T A, Eleazar J, Remotti F et al. Clear Cell and Eosinophilic Oncocytomas of Salivary Gland: Cytological Variants or Parallels? Diagnostic Cytopathology DOI 10.1002/dc
Rito M, Fonseca I. Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity ? Pathobiology 2018;85:85–95.
Majumdar A B, Paul S S , Sarker G, Ray S. Oncocytoma of Oral Cavity Mimicking as Jaw Tumor. Hindawi Publishing Corporation Case Reports in Otolaryngology Volume 2014, Article ID 315058, 5 pages.
Kar A, Pattnaik K, Kar T, Biswal P et al. Clear cell lesions in pathology: Histomorphologic approach to diagnosis. Indian Journal of Pathology and Microbiology 2020; 63( 2): 177-187.
Said-al-Naief N, Klein MJ. Clear cell entities of the head and neck: a selective review of clear cell tumors of the salivary glands. Head and Neck Pathol. 2008;2:111-5.
Brandwein M, Huvos A. Oncocytic tumors of major salivary glands: a study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15:514–528.
Shrestha P, Yang LT, Liu BL, et al. Clear cell carcinoma of salivary glands:immunohistochemical evaluation of clear tumor cells. Anticancer Res. 1994;14:825–836.
Woods T, Fitzpatrick S, Cohen D, Islam M et al. Clear cell changes in salivary gland neoplasms: A 20-year retrospective study. Oral Patol Oral Cir Bucal. 2017 May 1;22 (3):e276-81.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Nisha J Marla, Poorni Bharathi T
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
