Clinicopathological Analysis of Anterior-Superior Mediastinal Masses

Authors

  • Sarah Grace Priyadarshini
  • Ezhilvizhi Alavandar

DOI:

https://doi.org/10.21276/apalm.2984

Keywords:

Mediastinum, Thymoma, Lymphoma

Abstract

Background: The mediastinum is the space between the two lungs, bounded anteriorly by the sternum and posteriorly by the vertebral column. A spectrum of neoplastic and non-neoplastic lesions can arise in the mediastinum.

Methods: A total of 14 cases were retrospectively retrieved from the Histopathology department. The cases had histopathological diagnosis either in image guided, thorocoscopic, transbronchial or excision biopsies.

Results: The majority of cases (43% n=6) were of thymic origin, which included both neoplastic lesions of thymoma group and non-neoplastic lesion like thymic cysts. The thymoma group included 3 cases of thymoma B3 and 1 case of thymoma AB. The lymphoid lesions include Hodgkin lymphoma (14.3%; n=2) and non-Hodgkin lymphoma (7.1%; n=1). The mesenchymal lesions (21.4%; n=3) included lipoma, solitary fibrous tumor and schwannoma which accounts for one case each. A rare case of ectopic parathyroid adenoma (7.1%; n=1).  and a case of metastatic papillary carcinoma (7.1%; n=1) were also reported.

Conclusion: The diagnosis of mediastinal mass lesions can pose difficulties due to its wide clinicopathologic spectrum to the clinician, radiologists and pathologist. A multimodal approach with histopathological examination and immunohistochemistry can help in arriving at an accurate diagnosis.

Author Biographies

Sarah Grace Priyadarshini

Histopathology Department, Vijaya Hospital, Chennai

Ezhilvizhi Alavandar

Histopathology Department, Vijaya Hospital, Chennai

References

Sharma P, ,JHA V, Kumar N, Kumar R, Mandal A. Clinicopathologic analysis of mediastinal masses: A mixed bag of non-neoplastic and neoplastic etiologies. Turk Patoloji Derg. 2017; 33: 37-46

Aggarwal R, Rao S, Chopra P, Bhalla S, Vijay C L, Bin Asaf B, and Kumar A. Morphological spectrum of mediastinal lesions with special emphasis on evaluation of needle biopsy: An experience from a tertiary care hospital. Indian J Med Res. 2016; 144(4): 544–551

Dalal U, Dalal A, Kartik A, Saini V, Anand L. Clinicopathological Profile of Primary Mediastinal Masses: Our Experience. J Surg Anesth 4:1. doi: 10.35248/2684-1606.20.4.126

Dasgupta S, Bose D, Bhattacharyya NK, Saha M, Biswas K, Biswas P K. A clinicopathological study of mediastinal masses operated in a tertiary care hospital in Eastern India in 3 years with special reference to thymoma. Indian J Pathol Microbiol . 2016;59 (1):20-24.

Marino M, Ascani S. An overview on the differential diagnostics of tumors of the anterior-superior mediastinum: the pathologist’s perspective. Mediastinum 2019;3:6

Moran C, Suster S. Primary Parathyroid Tumors of the Mediastinum: A Clinicopathologic and Immunohistochemical Study of 17 Cases. Am J Clin Pathol 2005;124:749-754

Petkar M, Vaideeswar P, Deshpande JR. Surgical Pathology of Cystic Lesions of The Mediastinum. Journal of Postgraduate Medicine 2001; 47 (4): 235-239

Bakker M D, Marx A, Strobel P. Mesenchymal tumours of mediastinum. Virchows Arch 2015; 467: 487–500

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Published

30-05-2021

How to Cite

1.
Priyadarshini SG, Alavandar E. Clinicopathological Analysis of Anterior-Superior Mediastinal Masses. Ann of Pathol and Lab Med [Internet]. 2021 May 30 [cited 2024 Oct. 30];8(5):A131-135. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/2984

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Original Article