Incidence and Prognostic Implication of Bone Marrow Involvement in Hodgkin’s Lymphoma

Authors

  • Rimpi Bansal Department of Pathology, Gian Sagar Medical College And Hospital, Punjab. India
  • Puneet Kaur Department of Pathology, Gian Sagar Medical College And Hospital, Punjab. India
  • Jatin Sarin CCDC, Chandigarh, India
  • Anureet Kaur Department of Pathology, Gian Sagar Medical College And Hospital, Punjab. India
  • Akshita Sarin Government Medical College and hospital, Chandigarh India

DOI:

https://doi.org/10.21276/apalm.3010

Keywords:

Hodgkin’s Lymphoma, RS cells, Bone Marrow biopsy

Abstract

Introduction- : Conducting Bone marrow examination in a Hodgkin's Lymphoma (HL) patient  at the time of diagnosis is done routinely to determine the stage of the disease. The aim of this study was to analyze the incidence and prognosis of bone marrow involvement in patients with Hodgkins lymphoma, retrospectively.

 Materials and Patients: Ten patients of Hodgkins lymphoma were incorporated in the current study. Bone marrow aspiration and biopsy was done in all ten cases as part of staging procedure.

Results: Three patients showed involvement of bone marrow by Hodgkin’s lymphoma and both the patients had clinically poor outcome.

Discussion and Conclusion: Bone marrow examination is important in stage II and III of Hodgkinâ€s lymphoma because positive result will upstage the disease. Also, bone marrow involvement indicates an aggressive disease and poor prognosis for the patient.

References

Subramanian R, Basu D, Badhe B, Dutta TK. Role of Bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease. Indian J Pathol Microbiol 2007;50:640-3.

Cavalieri E, Anselmo AP, Gianfelici V, Frattarelli N, Pescarmona E, Foa R, et al. Is bone marrow trephine biopsy always mandatory in Hodgkin's disease? Haematologica 2005;90:134-6.

Munker R, HasencleverD, Brosteanu O, HillerE, Diehl V. bone marrow involvement in Hodgkin’s disease: an analysis of 135 consecutive cases. J Clin Oncol 1995, 13:403-409

FrancoV, Tripodo C, Rizzo A, Stella M, Florena AM. Bone marrow biopsy in Hodgkin's lymphoma. Eur J Haematol 2004;73:149-155.

Kini JR, Suresh PK, Sinha R, Sahu KK, Kumar S, Prasad K. Value of bone marrow examination in Hodgkin lymphoma: Report of three cases with review of literature. J Can Res Ther. 2012;8:457-459

Barbara J. Bain, David M. Clark, Bridget S. Lymphoproliferative Disorders. In Bone Marrow Pathology 4th edition. London: Willy-Blackwell. 2011; 300-420

Howell SJ, Grey M, Chang J, Morgenstern GR, Cowan RA, Deakin DP, Radford JA. The value of bone marrow examination in the staging of Hodgkin's lymphoma: a review of 955 cases seen in a regional cancer centre. Br J Haematol. 2002;119(2):408-411.

Kar R, Dutta S, Tyagi S. Clinically unsuspected Hodgkin's lymphoma diagnosed primarily from bone marrow trephine biopsy: Report of six cases. Indian J Pathol Microbiol. 2008;5:186-189.

Park Y, Park BB, Jeong JY, et al. Assessment of bone marrow involvement in patients with lymphoma: report on a consensus meeting of the Korean Society of Hematology Lymphoma Working Party. Korean J Intern Med. 2016;31(6):1030–1041. doi:10.3904/kjim.2015.006

Agbay RLMC, Loghavi S, Zuo Z, Fayad L, Dabaja B, Medeiros LJ, Khoury JD. Bone Marrow Involvement in Patients with Nodular Lymphocyte Predominant Hodgkin Lymphoma. Am J Surg Pathol. 2018 ;42(4):492-499.

Chauhan K, Jain M, Shukla P, Grover RK. Bone marrow involvement in Hodgkin's lymphoma: Data from a cancer hospital. Clin Cancer Investig J 2016;5:516-20

Moid F, DePalma L. Comparison of relative value of bone marrow aspirates and bone marrow trephine biopsies in the diagnosis of solid tumor metastasis and Hodgkin lymphoma. Arch Pathol Lab Med 2005;129:497-501.

Howard MR, Taylor PRA, Lucraft HH, Taylor MJ, Proctor SJ. Bone marrow examination in newly diagnosed Hodgkin's disease: Current practice in the United Kingdom. Br J Cancer 1995;71:210-212.

Wang J, Weiss LM, Chang KL, et al. Diagnostic utility of bilateral bone marrow examination: significance of morphological and ancillary technique study in malignancy. Cancer 2002; 94: 1522-1531.

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Published

02-12-2021

How to Cite

1.
Bansal R, Kaur P, Sarin J, Kaur A, Sarin A. Incidence and Prognostic Implication of Bone Marrow Involvement in Hodgkin’s Lymphoma. Ann of Pathol and Lab Med [Internet]. 2021 Dec. 2 [cited 2024 Nov. 19];8(11):A239-242. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3010

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Original Article