Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature
DOI:
https://doi.org/10.21276/apalm.3059Keywords:
sarcomatoid squamous cell carcinoma, spindle cell carcinoma, OSSN, ocular surface tumor, enucleationAbstract
Sacrcomatoid variant of squamous cell carcinoma has been known to involve numerous tissues like an aerodigestive tract, skin. A reddish mass of the left bulbar conjunctiva, with intraocular extension on ultra-bio-microscopy (UBM) was present. Histopathologic examination showed the characteristic spindle-shaped cells in continuity with the overlying epithelium with positive immunostains for cytokeratin, epithelial membrane antigen and vimentin. The presence of such an entity in the conjunctiva is rare and here we report such a case, this being the 37th case to be documented in literature. We also give a brief review of literature.
References
Sarma A, Das R, Sharma JD, Kataki AC. Spindle cell carcinoma of the head and neck: a clinicopathological and immunohistochemical study of 40 cases. Journal of Cancer Therapy. 2012; 3:1055-59.
Tabbara KF, Kersten R, Daouk N et al. Metastatic squamous cell carcinoma of the conjunctiva. Ophthalmology 1988; 95:318-21.
Lee GA, Hirst L W. Ocular surface squamous neoplasia. Surv Ophthalmol 1995; 39:429-50.
Shah BJ, Tupkari JV, Joy T. Sarcomatoid squamous cell carcinoma of mandible: A report of two cases. J Oral Maxillofac Pathol 2019; 23:163.
Cohen BH, Green WR, Iliff NT et al. Spindle cell carcinoma of the conjunctiva. Arch Ophthalmol 1980; 98:1809‑13.
Viswanathan S1, Rahman K, Pallavi S et al. Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre.Head Neck Pathol. 2010 Dec;4(4):265-75.
Huntington AC, Langloss JM, Hidayat AA. Spindle cell carcinoma of the conjunctiva. An immunohistochemical and ultrastructural study of six cases. Ophthalmology 1990; 97:711‑7.
Schubert HD, Farris RL, Green WR. Spindle cell carcinoma of the conjunctiva. Graefes Arch Clin Exp Ophthalmol 1995; 233:52‑3.
Seregard S1, Kock E. Squamous spindle cell carcinoma of the conjunctiva. Fatal outcome of a plerygium-like lesion. Acta Ophthalmol Scand. 1995 Oct;73(5):464-6.
Slusker‑Shternfeld I, Syed NA, Sires BA. Invasive spindle cell carcinoma of the conjunctiva. Arch Ophthalmol 1997; 115:288‑9.
Shields JA1, Eagle RC, Marr BP et al. Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. Cornea. 2007 Sep;26(8):1014-6.
Alkatan HM, Al-Motlak MA, Al-Shedoukhy AA. Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva.Saudi J Ophthalmol. 2010 Oct;24(4):155-8.
R Mittal, S Rath, GK Vemuganti. Ocular surface squamous neoplasia–Review of etio-pathogenesis and an update on clinico-pathological diagnosi. Saudi Journal of Ophthalmology. 2013; 27, (3)177-186
Coban-Karatas M, Bal N, Altan-Yaycioglu R et al. Spindle cell carcinoma of the conjunctiva: A rare entity. Indian J Ophthalmol. 2016;64(5):402–404.
Mehulkumar K. Patel, Sanjay V. Dhotre, Mahesh B. Patel et al. Case report of spindle cell carcinoma of the conjunctiva- a rare tumour International Journal of Current Research and Review. Dec 2016; 8(24):51-53
Cervantes G, RodrÃguez AA Jr., Leal AG. Squamous cell carcinoma of the conjunctiva: Clinicopathological features in 287 cases. Can J Ophthalmol 2002; 37:14‑9.
Ni C1, Guo BK. Histological types of spindle cell carcinoma of the cornea and conjunctiva. A clinicopathologic report of 8 patients with ultrastructural and immunohistochemical findings in three tumors.Chin Med J (Engl). 1990 Nov;103(11):915-20.
Penelope A McKelvie, Mark Daniell, Alan McNab et al. Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol. 2002; 86(2): 168–173.
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Copyright (c) 2021 Sahil Agrawal, Sujeeth Modaboyina, Seema Sen, Suman Kumari Meena, Saloni Gupta, Deepsekhar Das
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