Lobular Endocervical Glandular Hyperplasia: A case report
DOI:
https://doi.org/10.21276/apalm.3102Keywords:
Lobular Endocervical Glandular, HPV, CervixAbstract
Most cervical adenocarcinomas currently are HPV related. With increasing use of HPV vaccine, the prevalence of HPV related carcinomas may reduce & there might be relative increase in occurrence of non HPV related carcinomas. Gastric variant of cervical adenocarcinoma is one such HPV-independent carcinoma and recognized as distinct entity by WHO 2014. A spectrum of benign, premalignant and malignant endocervical lesions showing gastric differentiation have emerged in the past decade. Lobular endocervical glandular hyperplasia(LEGH) is one such benign precursor of gastric variant of cervical adenocarcinoma. We in this case report discuss various gross, histomorphologic, histochemical and immunohistochemical features of LEGH.
References
Hodgson A, Park KJ. Cervical Adenocarcinomas: A heterogeneous group of tumors with variable etiologies and clinical outcomes. Arch Pathol Lab Med. 2019;143 (1): 34–46.
Talia KL, McCluggage WG. The developing spectrum of gastric-type cervical glandular lesions. Pathology. 2018;50(2):122-133.
Mikami Y. Gastric-type mucinous carcinoma of the cervix and its precursors - historical overview. Histopathology. 2020;76(1):102-111.
Nucci MR, Clement PB, Young RH. Lobular endocervical glandular hyperplasia, not otherwise specified: a clinicopathologic analysis of thirteen cases of a distinctive pseudoneoplastic lesion and comparison with fourteen cases of adenoma malignum. Am J Surg Pathol. 1999;23(8):886-91.
Padrão IL and Andrade, Lucci De Angelo Andrade LA. Microglandular hyperplasia of the cervix: frequency in cone specimens, histological patterns, clinical aspects and immunohistochemical markers for differential diagnosis with adenocarcinoma. Jornal Brasileiro de Patologia e Medicina Laboratorial [online]. 2006; 42:3
Ishii S, Ito T, Yamada M, Yamazaki N, Ikebata K, Fujiyama J, et al. Characteristic Cytological Findings of Lobular Endocervical Glandular Hyperplasia Associated with Adenocarcinoma of the Uterine Cervix. Acta Cytol. 2020;64:556-562
Kobara H, Miyamoto T, Otsuki T, Ohya A, Shiozawa T. Worsening cytology and lesion enlargement are useful indicators for malignant transformation of lobular endocervical glandular hyperplasia during follow-up: A case report. Gynecol Oncol Rep. 2020;32:100571.
Omori M, Kondo T, Tagaya H, Watanabe Y, Fukasawa H, Kawai M, et al. Utility of imaging modalities for predicting carcinogenesis in lobular endocervical glandular hyperplasia. PLoS One. 2019;14(8):e0221088.
Yuan CT, Lin MC, Kuo KT, Wang TH, Mao TL. Gastric-type adenocarcinoma in situ of uterine cervix: cytological and histopathological features of two cases. Virchows Arch. 2016;469(3):351-6.
Kojima A, Shimada M, Mikami Y, Nagao S, Takeshima N, Sugiyama T. Gynecology Study Group. Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group. Int J Gynecol Cancer. 2018;28(1):99-106.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Kunjal Lila, Roshani Hansraj Gala
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).