To Study the Role of Bone Marrow Aspiration in Etiological categorization of Pediatric Pancytopenia
DOI:
https://doi.org/10.21276/apalm.3172Keywords:
Leukemia, Pancytopenia, Megaloblastic Anemia, AML, ALLAbstract
Background: Pancytopenia is a Clinico-hematological entity, characterized by a triad of Anemia, leucopenia, and thrombocytopenia. The criterion for defining Pancytopenia is HGB < 9 g/dl: ANC < 1.5 x 109/L and platelet count <100 x 109/L. The main objective of this study is to categorize pediatric pancytopenia’s on etiological basis and to study the age wise incidence.
Methodology and Results: This is a 5-year study (2016-2021) conducted in tertiary care pediatric referral hospital. All data were expressed as Mean +/ - SD and p value <0.05 is taken as statistically significant. A total of 500 bone marrow smears of pancytopenic patients were studied, of which 60% were boys & 40% girls, 64% constituted Malignant diseases and 36% were benign. Incidence wise, ALL is the most common and pancytopenia being 2nd and together comprises 64% of total cases. Some rare cases like AML –M6 in 2 months old, Chediak higashi syndrome and Familial Hemophagocytic syndrome were noted. Flow cytometry and Molecular genetics were done were ever required.
Conclusion: Bone Marrow Aspiration is a reliable and sensitive test which can be used in investigation of Pediatric pancytopenia’s and if used meticulously with other routine hematological tests can give a high diagnostic accuracy. ALL is most common in our study (other studies showed Aplastic anemia), AML-M6 in 2 months, LD bodies in bone marrow, HPS were amongst the rare cases
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Copyright (c) 2022 Mirza Asif Baig, Swamy KB, Fawzia Sharaf, Ibrahim Mehmood, Ameen K Baksh, Yasser Moshrif, Ahmed Bahashwan, Sara Mahajabeen, Lama El Attar, Nabeel Al Mutairi, Anas Khan, Hajer Al Harbi, Iqbal Multani, Nawal Al Mutairi, Mishal Al sulami, Nader Al Harbi, Marwa Al Harbi
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