Solid Papillary Carcinoma: A Clinicopathological Evaluation of a Rare Variant of Carcinoma Breast
DOI:
https://doi.org/10.21276/apalm.3200Keywords:
Solid papillary carcinoma, Breast papillary carcinoma, Neuroendocrine differentiation, Nodal involvementAbstract
Background: Solid papillary carcinoma (SPC) of the breast is considered a low grade carcinoma with a favorable prognosis. We aimed to describe clinicopathologic features including immunohistochemistry expression profile and to delineate adverse prognostic features, if any.
Methods: Patients diagnosed with SPC between the years 2016–2022 were retrospectively identified from the archives at Kailash Cancer Hospital and Research Centre, Goraj. Microscopic slides and clinical history were reviewed. Immunohistochemical stains were performed.
Results: Of 12 SPCs cases retrieved, 11 (92%) were associated with ductal carcinoma in situ (DCIS). The median tumour size was 1.6cm (range 1.3-7.0cm). All tumors were positive for hormone receptor expression and negative for HER-2Neu. 6 cases (50%) show neuroendocrine differentiation. Lymph node involvement was identified in 4/12 (33.3%) patients. Of 12 patients with outcome data (median follow-up 30 months, range 7-72 months), none (0%) developed local recurrence. No distant metastasis or deaths were observed.
Conclusions: SPCs has excellent prognosis with no local recurrence or distant metastasis in this study. Axillary node metastasis is found to be associated with larger tumor size, however it appears to have no impact on disease free or overall survival.
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Copyright (c) 2022 Dhruvi Neel Shah, Yogesh Mistry, Bhawana Chaudhry, Rakshit Shah
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