Acute Lymphoblastic Leukemia With Surface Light Chain Expression
DOI:
https://doi.org/10.21276/apalm.3214Keywords:
Acute Lymphoblastic leukemia, , surface immunoglobulin light chainAbstract
Acute Lymphoblastic leukemias (ALL) are a heterogeneous group of neoplasms which can either be having precursor B cell immunophenotype or mature B cell immunophenotype. Surface immunoglobulin light chain restriction is usually a feature of mature B cell neoplasms. A precursor B cell lymphoblastic leukemia (pre-B-ALL) with surface immunoglobulin light chain expression is a rare immunophenotype . We report a case of a 4 year old female with L1 type of blast morphology yet showing surface light chain restriction. Recognizing this rare immunophenotype and arriving at a correct diagnosis has therapeutic implications as treatment regimens differ for precursor B ALL as compared to mature B cell neoplasms.
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Copyright (c) 2023 Kalyani Bapat, Dia Mansukhani, Shanaz Khodaiji, Sachin Almel
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