Pediatric Acute Promyelocytic Leukemia: A Rare Case Report
DOI:
https://doi.org/10.21276/apalm.3254Keywords:
Disseminated intravascular coagulation, all-trans retinoic acid, hypergranular, microgranular, paediatric APMLAbstract
Acute Promyelocytic leukemia (APML) belongs to French American British (FAB) classification M3 subtype of acute myeloid leukemia & is characterized by t(15;17) and resultant PML-RARA fusion gene. APML accounts for 5-10 % in pediatric age group. Patients usually present with bleeding manifestations, weakness and increased propensity for disseminated intravascular coagulation. Extramedullary involvement is rare. It is a hematologic disease presenting as medical emergency and can be diagnosed with certainty by morphological examination of peripheral blood film & bone marrow aspirate to allow initiation of targeted therapy in order to reduce mortality. Patients with APML receive combination of all-trans retinoic acid (ATRA) & arsenic trioxide to induce terminal differentiation of blasts. We present a case of APML in a four years old child presented in the department of clinical hematology with pallor, lymphadenopathy and hepatosplenomegaly.
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Copyright (c) 2023 Renuka Verma, Aakanksha Rawat, Rajnish Kalra, Monika Gupta, Anjali Ahlawat, Pooja Rathee
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