Peritoneal De-differentiated Liposarcoma: A Rare Case Report

  • Gauri Vinod Hardas Pathology, KIMS-Kingsway Hospitals, Nagpur, Maharashtra
  • Lalit Lad Pathology, KIMS-Kingsway Hospitals, Nagpur, Maharashtra
  • Harshwardhan Bora Pathology, KIMS-Kingsway Hospitals, Nagpur, Maharashtra
  • Saurabh Prasad Pathology, KIMS-Kingsway Hospitals, Nagpur, Maharashtra
Keywords: De-differentiated liposarcoma, Immunohistochemistry

Abstract

Peritoneal de-differentiated liposarcoma is a rare malignancy with a poor prognosis. Our patient, 67 years/Male presented with complaints of constipation & distension of abdomen for one month. Initially based on histology, diagnosis of Gastrointestinal Stromal Tumor (GIST) was thought. On PET scan, he had multiple peritoneal deposits & serosal deposits along recto-sigmoid colon and ileal loop which on immunohistochemistry (IHC) proved to be de-differentiated liposarcoma. The patient was given chemotherapy. Patient responded well to treatment. Such peritoneal tumors pose a challenge to the pathologist as only morphology is not of much help & IHC becomes necessity.

References

Bostanoğlu A, Yıldız B, Kulaçoğlu S, et al. Primary liposarcoma of the stomach. Turk J Gastroenterol. 2013;24(2):167-9.

Thway K. Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. Semin Diagn Pathol. 2019 Mar;36(2):112-121.

McCormick D, Mentzel T, Beham A, et al. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol. 1994 Dec;18(12):1213-23.

Graham DS, Qorbani A, Eckardt MA, et al. Does "Low-Grade" Dedifferentiated Liposarcoma Exist? The Role of Mitotic Index in Separating Dedifferentiated Liposarcoma From Cellular Well-differentiated Liposarcoma. Am J Surg Pathol. 2023 Jun 1;47(6):649-660.

Binh MB, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005 Oct;29(10):1340-7.

Horvai AE, Schaefer JT, Nakakura EK, et al. Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas. Mod Pathol. 2008 May;21(5):517-24.

Park N, Kuk JC, Shin EJ, et al. Surgery of intraabdominal giant dedifferentiated liposarcoma of ascending colon mesentery: A rare case report. Int J Surg Case Rep. 2022 Sep;98:107482.

Cha EJ. Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass. World J Gastrointest Oncol. 2011 Jul 15;3(7):116-8.

Dhakal S, Prajapati I. Dedifferentiated liposarcoma of small bowel mesentery: a rare case report. J Surg Case Rep. 2022 Jan 18;2022(1):rjab599.

Sawayama, H., Yoshida, N., Miyamoto, Y. et al. Primary colonic well-differentiated / dedifferentiated liposarcoma of the ascending colon: a case report. surg case rep 3, 96 (2017).

Published
19-10-2023
Section
Case Report