Adenoid Cystic Carcinoma of Breast: A Common Tumour at An Uncommon Site - A Case Report and Literature Review
DOI:
https://doi.org/10.21276/apalm.3277Keywords:
Adenoid cystic carcinoma, breast, triple negative, malignant tumourAbstract
Adenoid Cystic Carcinoma is an uncommon malignancy of breast with favourable prognosis and distinct histomorphology. We present a case of 47 year old female with palpable lump in right breast. Mammogram revealed an irregular hypoechoic solid mass at 10 ‘O clock position with indistinct margins. Trucut biopsy sections revealed a tumour showing pseudoglandular and true gland-like spaces lined by epithelial and myoepithelial cells and filled with abundant homogenous eosinophilic material. Immunohistochemistry revealed triple negative tumour cells, low Ki 67 (1-2 %) with p63 positive in myoepithelial cells and CD117 positive in epithelial cells. With these findings, it was opined as Adenoid cystic carcinoma right breast and the patient underwent wide local excision which we received for histopathological examination. On serial slicing, a solid circumscribed tumour measuring 1x1x2 cm was seen. Sections revealed concurrent morphological and IHC findings as seen on trucut biopsy. Patient responded well to surgery followed by radiotherapy.
References
Kashiwagi S, Asano Y, Ishihara S, Morisaki T, Takashima T, Tanaka S et al. Adenoid Cystic Carcinoma of the Breast: A Case Report. Case Rep Oncol. 2019;12:698-703.
Canyilmaz E, Uslu GH, Memış Y, Bahat Z, Yildiz K, Yoney A. Adenoid cystic carcinoma of the breast: A case report and literature review. Oncol Lett. 2014;7:1599-1601.
Bhosale SJ, Kshirsagar AY, Patil RK, Wader JV, Nangare N, Patil PP. Adenoid cystic carcinoma of female breast: A case report. Int J Surg Case Rep. 2013;4:480-2.
Kocaay AF, Celik SU, Hesimov I, Eker T, Percinel S, Demirer S. Adenoid Cystic Carcinoma of the Breast: A Clinical Case Report. Med Arch. 2016;70:392-4.
Pang W, Wang Z, Jin X, Zhang Q. Adenoid cystic carcinoma of the breast in a male: A case report. Medicine (Baltimore). 2019;98:e16760.
6. Mhamdi HA, Kourie HR, Jungels C, Aftimos P, Belbaraka R, Piccart-Gebhart M. Adenoid cystic carcinoma of the breast - an aggressive presentation with pulmonary, kidney, and brain metastases: a case report. J Med Case Rep. 2017;11:303.
7. Marinho ML, Tafuri A, Ramos CAS, Ladeia AAL, Azevedo LC. Adenoid cystic carcinoma of the breast: case report. Mastology. 2021;31:e20210009.
8. Rabban JT, Swain RS, Zaloudek CJ, Chase DR, Chen YY. Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol. 2006;19:1351-7.
Zhang M, Liu Y, Yang H, Jin F, Zheng A. Breast adenoid cystic carcinoma: a report of seven cases and literature review. BMC Surg. 2022;22:113.
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Copyright (c) 2023 Gurpreet Kaur Walia, Poonam Yadav, Natasha Dogra, Surjeet Dwivedi, Ramanjit Singh Akal
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