Primary Liver Small Cell Carcinoma Masquerading as Cholangiocarcinoma - A Rare Case Report

  • Gauri Vinod Hardas Pathology, KIMS-Kingsway Hospitals
  • Saurabh Prasad Oncology KIMS-Kingsway Hospitals
Keywords: Extra-pulmonary small cell carcinoma, liver, immunohistochemistry

Abstract

Primary liver small cell carcinoma is a rare malignancy with poor prognosis. Our patient, 44 years old male presented with the symptoms of abdominal pain, decreased appetite & black colored watery stool since one month. On PET -CT he had multiple rounded lesions in liver which were thought to be cholangiocarcinoma initially. Biopsy & immunohistochemistry were performed & it was found to be small cell carcinoma. Patient was managed with chemotherapy. Being rare, it is necessary to do proper typing of such tumor so that patient gets benefited by specific treatment. Further, it also helps to know the prognosis.

References

Levenson RM , Ihde DC, Matthews MJ, et al. Small cell carcinoma presenting as an extrapulmonary neoplasm: sites of origin and response to chemotherapy. J Natl Cancer Inst. 1981 Sep;67(3):607-12

Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol. 1992;20(2):89-99

Eriguchi N, Aoyagi S, Noritomi T, et al. Adeno-endocrine cell carcinoma of the gallbladder. J Hepatobiliary Pancreat Surg. 2000;7(1):97-101

Nakamura Y, Tajiri T, Uchida E, et al. Changes to levels of serum neuron-specific enolase in a patient with small cell carcinoma of the pancreas. J Hepatobiliary Pancreat Surg. 2005;12(1):93-8

Sugawara G, Yamaguchi A, Isogai M, Watanabe Y, Kaneoka Y, Suzuki M. Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report. J Hepatobiliary Pancreat Surg. 2004;11(1):56-60

Walenkamp AM, Sonke GS, Sleijfer DT. Clinical and therapeutic aspects of extrapulmonary small cell carcinoma. Cancer Treat Rev. 2009 May;35(3):228-36

Fischer BM, Mortensen J, Langer SW, et al. A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis. Ann Oncol. 2007 Feb;18(2):338-45

Cho SB, Park SY, Joo YE. Small cell carcinoma of extrahepatic bile duct presenting with hemobilia. Korean J Gastroenterol. 2009 Sep;54(3):186-90

Choi SJ, Kim JM, Han JY, et al. Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings. Yonsei Med J. 2007 Dec 31;48(6):1066-71

Jo JM, Cho YK, Hyun CL, et al Small cell carcinoma of the liver and biliary tract without jaundice. World J Gastroenterol 2013; 19(44): 8146-8150

Morikawa H, NakayamaY, Maeda T, et al. A case of primary small cell carcinoma liver that was treated with chemotherapy.Hepatol Int2,500-504(2008)

Dravid A, Natarajan K, Medisetty M, et al. (2017) Primary small cell carcinoma of liver in a HIV/Hepatitis B co-infected patient on virologically suppressive antiretroviral therapy: case report & literature review. Oncol cancer case Rep3:137.

Kim YH, Kwon R, Jung GJ, Roh MH, Han SY, Kwon HC, Jeong JS, Shin TB, Oh JY, Lee KN. Extrapulmonary small‐cell carcinoma of the liver. Journal of Hepato‐Biliary‐Pancreatic Surgery. 2004 Oct;11(5):333-7.

Zanconati F, Falconieri G, Lamovec J, Zidar A. Small cell carcinoma of the liver: a hitherto unreported variant of hepatocellular carcinoma. Histopathology. 1996 Nov;29(5):449-53.

Published
05-01-2024
Section
Case Report