Morphological Spectrum of Intracranial Space Occupying Lesions at Tertiary Care Hospital: A Clinicopathological Study
DOI:
https://doi.org/10.21276/apalm.3328Keywords:
ICSOLs, Astrocytoma, Meningioma, Pineal parenchymal tumorAbstract
Background: An "Intracranial Space-Occupying Lesion" (ICSOL) is defined as a mass lesion in the cranial cavity with diverse etiology, such as benign or malignant neoplasm, inflammatory or parasitic lesion, hematoma, or arteriovenous malformation.
Materials and Methods: Biopsies of 202 cases of intracranial space-occupying lesions were received in the Department of Pathology, B.J. Medical College, Ahmedabad, during the period of December 2022 to May 2023. All specimens were preserved in 10% formalin and allowed to fix for 24 hours. Paraffin-embedded sections of 5 microns were cut, and the Hematoxylin and Eosin-stained sections of the CNS lesions were studied.
Results: Out of the total 202 cases, 176 were neoplastic lesions and 26 were non-neoplastic lesions. Among the 176 neoplastic intracranial tumors, 173 (98.3%) were primary, and 3 (1.7%) were metastatic. The most common type of intracranial tumor was Meningioma (33 cases, 18.6%), followed by Astrocytoma (31 cases, 17.5%). The most common age group affected by neoplastic lesions was 21-30 years, followed by the 31-50 years age group. The most common age group with non-neoplastic lesions was 31-40 years. Among the 26 cases of non-neoplastic intracranial lesions, 20 cases of cystic lesions and 6 cases of cerebral abscess were encountered.
Conclusion: The surgical pathologist plays an important role in the accurate diagnosis of various intracranial space-occupying lesions, which is of immense help for patient prognosis and treatment [3]. Histopathological study remains the gold standard for the diagnosis and grading of tumors, on which clinicians can decide the further line of management.
References
Young B, Woodford P, O'Dowd G. Wheater's Functional Histology: A Text and Colour Atlas. 6th ed. Philadelphia: Elsevier; 2013. p. 384-401.
Kumar V, Abbas AK, Aster JC. Robbins & Cotran Pathologic Basis of Disease. 10th ed. Philadelphia: Elsevier; 2021. p. 1293-1302.
Anadure NH, Ravindra RS, Karnappa AS. Morphological spectrum of intracranial lesions in a tertiary care hospital in North Karnataka: A clinicopathological and immunohistochemical study. J Clin Diagn Res. 2016 Aug;10(8)
Butt ME, Khan SA, Chaudhry NA, Qureshi GR. Intracranial space occupying lesions: A morphological analysis. Biomedica. 2005;21:31-5.
Joshi H, Awasthi S, Dutta S. Histopathological spectrum of central nervous system lesions. Int J Med Sci Diagn Res. 2019 Nov;5(11).
Naik S, Sahoo N, Mohanty B, et al. Histopathological spectrum of central nervous system lesions in a tertiary care hospital in Eastern India. J Evid Based Med Healthc. 2021;8(18):1304-10.
Rathod V, Bhole A, Chauhan M, Ramteke H, Wani B. Study of clinico-radiological and clinico-pathological correlation of intracranial space occupying lesion at a rural center. Internet J Neurosurg. 2009;7(1).
Gunge RA, Munemane A, Karle RR. Histopathological overview of CNS tumors at a tertiary care hospital. Indian J Basic Appl Med Res. 2018 Jun;7(3):86-99.
Madabhushi V, Venkata RI, Garikaparthi S, Kakarala SV, Duttaluru SS. Role of immunohistochemistry in diagnosis of brain tumors: A single institutional experience. J NTR Univ Health Sci. 2015.
Kothari F, Shah A. Prospective study of intracranial tumors. SEAJCRR. 2014;3(5):918-32.
Kanthikar SN, Nikumbh DB, Dravid NV. Histopathological overview of central nervous system tumors in North Maharashtra, India: A single center study. Indian J Pathol Oncol. 2017;4(1):80-4.
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Copyright (c) 2024 Payal Jayprakash Soniya, Meena Avinash Patel, Shivani Harishankar Dixit, Hansa Goswami
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