An Autopsy Study of Histopathological Examination of Coronary Atherosclerosis by Modified American Heart Association Classification in a Tertiary Care Centre

  • Aesha Amrish Parikh Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
  • Hemina Himanshu Desai Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
  • Rutul Amrish Parikh Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
  • Twinkle Bhashyantkumar Thakkar Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
  • Bhumi Rameshchandra Bhuva Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
  • Hansa Goswami \Pathology Department, B.J. Medical College and Civil Hospital, Asarva, Ahmedabad, Gujarat, India
DOI: https://doi.org/10.21276/apalm.3338
Keywords: Atherosclerosis, Autopsy, Coronary artery disease, Atheromatous plaque

Abstract

Background: The study was conducted to assess the atherosclerotic lesions in coronary arteries in autopsy cases, grading them with reference to the Modified American Heart Association (AHA) classification. It also aimed to evaluate atheromatous plaques to determine the age and sex-related prevalence of atherosclerosis at B.J. Medical College, Ahmedabad. Methods: Autopsies were conducted on 100 cases between the ages of 10-75 years, during the period from January 2023 to July 2023, using conventional techniques. A microscopic assessment of two main coronary arteries was performed. Results: According to the Modified AHA classification of atherosclerosis, the maximum number of cases belonged to the 40-49 years age group (46 cases), followed by the 21-39 years age group (29 cases). Out of the 100 cases, 85 were male and 15 were female. The degree of atherosclerosis in the left coronary artery (LCA) was greater in comparison to the right coronary artery (RCA). Pathological intimal thickening (PIT), intimal thickening (non-atherosclerotic), and calcified nodules were common lesions found in these coronaries. PIT was the most common lesion involving the coronaries and is the precursor lesion for the development of advanced lesions. Conclusion: Coronary artery disease is reaching pandemic proportions, so the study of subclinical atherosclerosis is crucial to estimate the disease burden in the asymptomatic population. Autopsy-based studies for evaluating the prevalence of atherosclerosis in a population are cost-effective procedures and help in estimating the future disease burden in the population.

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Published
11-07-2024
Issue
Vol 11 No 7 (2024)
Section
Original Article

Copyright (c) 2024 Aesha Amrish Parikh, Hemina Himanshu Desai, Rutul Amrish Parikh, Twinkle Bhashyantkumar Thakkar, Bhumi Rameshchandra Bhuva, Hansa Goswami

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