Transfusion Effect of Single and Random Donor Platelets in Thrombocytopenic Pediatric Patients with Hematological Malignancy at Tertiary Care Hospital
Abstract
Background This study was performed to assess differences between Single Donor Platelets (SDP) and Random Donor Platelets (RDP) by evaluating the platelet increment in the form of corrected count increment (CCI), platelet transfusion reaction rates, and the development of refractoriness after multiple platelet transfusions. Material and Methods In this two-year prospective study performed at a tertiary care hospital, dose response to platelet transfusions was studied in 68 newly diagnosed pediatric patients with hematological malignancies admitted for induction chemotherapy. The study was divided into three groups based on the type of platelet transfusion received: RDP group: Patients who exclusively received Random Donor Platelets. SDP group: Patients who exclusively received Single Donor Platelets. RDP+SDP group: Patients who received both RDP and SDP. Statistical Analyses Used: Chi-Squared test. Results CCI at the end of one hour (1-HR) and 24 hours (24-HR) was significantly greater in the SDP group (p-value 0.0003 and 0.0001, respectively), showing better platelet count increment after SDP transfusion. In the SDP group, the increments after the first and last transfusions were in the same range, whereas in the RDP group, the increments decreased from the first to the last transfusion. Thus, the use of SDPs postponed refractoriness. Maximum cases of the RDP group showed platelet refractoriness (50%), of which 76% were refractory due to an immune cause. The majority of acute platelet transfusion reactions were seen in the RDP group (38.98%), with the most common reaction being febrile non-hemolytic transfusion reaction. Conclusion The SDP group showed a better response to platelet transfusion than the other groups (RDP group and RDP+SDP group).References
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