Mixed Small Cell Carcinoma and Mucinous Adenocarcinoma of Appendix: A Rare Case Report with Review of Literature

Authors

  • Renu Sukumaran Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India
  • Thattungal Manoharan Anoop Department of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

DOI:

https://doi.org/10.21276/apalm.3344

Keywords:

Appendix, mucinous adenocarcinoma, neuroendocrine non-neuroendocrine neoplasms, small cell carcinoma of the appendix

Abstract

Gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are a heterogeneous group of tumors showing different morphological and prognostic features. The biological behavior of MiNEN is mostly driven by its high-grade component. Due to limitations in diagnostic methods and poor awareness, the incidence of MiNEN may be underestimated. The pathogenesis of MiNEN remains controversial. Molecular studies point towards a common monoclonal origin of the two components. Mixed tumors of the appendix are quite rare compared with those occurring elsewhere in the gastrointestinal tract. Although the appendix represents a common site of intestinal neuroendocrine tumors, primary extrapulmonary small cell carcinoma of the appendix is a rare entity. We describe a unique case of primary combined adenocarcinoma and small cell carcinoma of the appendix.

References

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Published

26-05-2024

How to Cite

1.
Sukumaran R, Anoop TM. Mixed Small Cell Carcinoma and Mucinous Adenocarcinoma of Appendix: A Rare Case Report with Review of Literature. Ann of Pathol and Lab Med [Internet]. 2024 May 26 [cited 2024 Dec. 5];11(6):C71-75. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3344

Issue

Section

Case Report