Correlation and Expression of ER, PR, HER-2/Neu and Its Association with Clinicopathological Variables in Invasive Ductal Carcinoma of Breast

Authors

  • Deepthi Chandrika Chintalapudi Department of Pathology, GSL Medical College, Hospital and Research Centre, Rajamahendravaram, Andhra Pradesh, India
  • Bindu Madhavi Rajulapati Department of Pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India
  • Satya Prakash Turlapati Department of Pathology, GSL Medical College, Hospital and Research Centre, Rajamahendravaram, Andhra Pradesh, India

DOI:

https://doi.org/10.21276/apalm.3374

Keywords:

Invasive Ductal Carcinoma Breast, Estrogen Receptors, Progesterone Receptor, Her-2/Neu, c-erbB-2 Proto-Oncogene

Abstract

Background: Invasive ductal carcinoma (IDC) of the breast is the largest group of malignant mammary tumors, comprising approximately 75% of mammary carcinomas. The prognosis of breast cancer depends on the histological type, size of the tumor, tumor necrosis, skin, nipple, and chest wall invasion, lymphovascular invasion, grade, stage, and the status of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. These factors are especially important in planning therapy and for clinical follow-up.

Materials and Methods: A total of 114 cases with IDC who underwent modified radical mastectomy and were diagnosed as malignant on histopathology were collected from the Department of Pathology from January 2022 to January 2024. Immunohistochemistry (IHC) for ER, PR, and HER-2 status was evaluated by histopathologists following the College of American Pathologists (CAP) guidelines. Statistical analysis was performed using SPSS software versions 21 and 23 for Windows, with the chi-square test and Pearson correlation test used to determine the quantitative data.

Results: Our results showed that most of the breast cancer patients (53.6%) were aged 50 and above. The mean age of the patients was 51.1 ± 2.3 years (ranging from 30 to 75 years). Forty-six (40.4%) and 30 (26.3%) cases were positive for ER and PgR, respectively, and 24 cases (21.1%) were positive for HER-2. We also observed a significant positive correlation between ER and PR expression (P = 0.00), and they inversely correlated with HER-2/neu expression (P = 0.02).

Conclusion: The ER/PR/HER2 subtyping is simple, inexpensive, easy to interpret, reliable, reproducible, and readily available for clinicians without additional tests. It provides valuable prognostic information for making the best therapeutic decisions.

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Published

11-08-2024

How to Cite

1.
Chintalapudi DC, Rajulapati BM, Turlapati SP. Correlation and Expression of ER, PR, HER-2/Neu and Its Association with Clinicopathological Variables in Invasive Ductal Carcinoma of Breast. Ann of Pathol and Lab Med [Internet]. 2024 Aug. 11 [cited 2024 Oct. 5];11(8):A213-221. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/3374

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