Serum aminotransferase activity in patients of epilepsy and mania taking sodium valproate.

Authors

  • Asha Khubchandani
  • Vijay R Parmar B.J.MEDICAL COLLEGE, GUJARAT UNIVERSITY
  • Janki Jadav
  • Gagandeep Sidhu
  • Viral Solanki
  • Sagar Gangwani
  • Meghna Solanki

Keywords:

Aminotransferase, Epilepsy, Mania, Sodium Valproate

Abstract

Background: Our aim is to study the serum aminotransferase activity in patients of epilepsy and mania taking sodium valproate.  Sodium valproate is a common drug to be prescribed to the patients of epilepsy and mania. Aminotransferase, both AST (Aspartate amino transferase) and ALT (Alanine amino transferase) is an accepted marker for any liver injury.

Methods:  Serum sample of fifty patients of known cases of epilepsy and mania, who were on sodium valproate since at least 3 month and fifty normal subjects were taken. Serum aminotransferase level (both AST & ALT) were estimated by colorimetric method in fully automated Erba XL-640 Analyser.

Results: The level of aminotransferase enzymes were  increased in patients of epilepsy and mania after administration of sodium valproate and elevation was highly significant  as compared to the normal subjects (p value <0.05).

Conclusion: From our study it is concluded that there is a need for monitoring serum aminotransferase level in patients receiving sodium valproate.

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Published

17-07-2014

How to Cite

1.
Khubchandani A, Parmar VR, Jadav J, Sidhu G, Solanki V, Gangwani S, et al. Serum aminotransferase activity in patients of epilepsy and mania taking sodium valproate. Ann of Pathol and Lab Med [Internet]. 2014 Jul. 17 [cited 2024 Nov. 19];1(1):20-3. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/42

Issue

Vol. 1 No. 1 (2014)

Section

Original Article

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Copyright (c) 2014 Asha Khubchandani, Vijay R Parmar, Janki Jadav, Gagandeep Sidhu, Viral Solanki, Sagar Gangwani, Meghna Solanki

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