Evaluation of pattern of angiogenesis in various menstrual disorders in different district in Gujarat, India.

Authors

  • Killol Nathubhai Desai Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh
  • Vidya Kantilal Satapara Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India

Keywords:

Angiogenesis, menstrual disorders, dysfunctional uterine bleeding, endometrium

Abstract

Backgound: Menstrual disturbance is one of the commonest gynecological problems. Majority of these women have dysfunctional uterine bleeding (DUB), the rest being associated with leiomyomas, carcinomas, adenomyosis, endometrial polyps, hyperplasia and oral contraceptive uses.

Aims:  To study of alteration in blood vessels morphology in various menstrual disorders have significant role in prognosis and in various anti-angiogenic therapies.

Methods : A Cross-sectional study done at Anand, Surendranagar and Junagadh district from October 2011 to October 2016. 1867 endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. 761 cases were taken as control and 1106 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility, atrophic endometrium, endometrial hyperplasia, pill endometrium and carcinomas. Using light microscopy, the vascular morphology was studied. Statistical analyses were performed using the IBM SPSS (Statistical package for the Social Sciences v15.0) and Microsoft Excel 2007 software.

Results: The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB.

Conclusions: The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.

 

DOI: 10.21276/APALM.1180

Author Biographies

Killol Nathubhai Desai, Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh

Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh

Vidya Kantilal Satapara, Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India

Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India

References

1. Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In: Kurman RJ. Blaustein’s pathology of the female genital tract, 5th ed. USA: Springer; 2002. 421-66.
2. Mints M, Blomgren B, Falconer C, Fianu-Jonasson A, Plamblad J.Microvascular density, vascular endothelial growth factor A and its receptors in endometrial blood vessels in patients with menorrhagia. Fertil Steril 2005;84:692-700.
3. Upadhyay SN, Mishra J. Observations on histopathological changes in the uterus in dysfunctional uterine bleeding. J Obstet Gynaecol India 1963;13:531-41.
4. Sahasrabudhe NS, Dalal SR, Jadhav MV. Endometrial blood vessels in health and disease. Med J West India 2000;28:27-31.
5. Hourihan HM, Sheppard BL, Bonnar J. A morphometric study of the effect of oral norethisterone or levonoregestrel on endometrial blood vessels. Contraception 1986;34:603-12.
6. Shaw ST, Macaulay LK, Hohman WR. Vessel density in endometrium of women with and without intrauterine contraceptive devices: a morphometric evaluation. Am J Obstet Gynecol 1979;135:202-6.
7. Fanger H, Barker BE. Capillaries and arterioles in normal endometrium. Obstet Gynaecol 1961;17:543-50.
8. Nayha V, Viitanen T, Stenback F. Altered extent, pattern and characteristics of microvascular density are indicators of Neoplastic progression in the endometrium. Int J Cancer 2005;115:975-80.
9. Rees MC, Dunhill MS anderson AB, Turnbull AC. Quantitative uterine histology during the menstrual cycle in relation to measured menstrual blood loss. Br J Obstet Gynaecol 1984;91:662-6.
10. Abulafia O, Triest WE, Sherer DM, Hansen CC, Ghezzi F. Angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma. Obstet Gynecol 1995;86:479-85.
11. Abulafia O, Sherer DM. Angiogenesis of the endometrium. 1999;94:148-53.
12. Hickey M, Fraser IS. Clinical implications of disturbances of uterine vascular morphology and function. Baillière’s Clin Obstet Gynecol 2000;14:937-51.
13. Sippe G. Endometrial hyperplasia and uterine bleeding. J Obstet Gynaecol 1962;69:1015-9.
14. Farrer-Brown G, Beilby JOW, Tarbit MH. The vascular patterns in myomatous uteri. J Obstet Gynaecol Br Commonw 1970;77:967-75.
15. Beilby JO, Farrer-Brown G, Tarbit MH. The microvasculature of common uterine abnormalities, other than fibroids. J Obstet Gynaecol Br Commonw 1971;78:361-8.
16. Edi-Osagie EC, Seif MW, Aplin JD, Jones CJ, Wilson G, Lieberman BA. Characterizing the endometrium in unexplained and tubal factor infertility: a multiparametric investigation. Fertil Steril 2004:82:1379-89.
17. Steer CV, Tan SL, Mason BA, Campbell S. Midluteal-phase vaginal color doppler assessment of uterine artery impedance in a subfertile population. Fertil Steril 1994;61:53-8.
18. Hickey M, Lau TM, Russell P, Fraser IS, Rogers PA. Microvascular density in conditions of endometrial atrophy. Hum Reprod 1996;11:2009-13.

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Published

04-06-2017

How to Cite

1.
Desai KN, Satapara VK. Evaluation of pattern of angiogenesis in various menstrual disorders in different district in Gujarat, India. Ann of Pathol and Lab Med [Internet]. 2017 Jun. 4 [cited 2024 Nov. 2];4(3):A254-260. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1180

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