Immunohistochemical Profile of Lung Tumors in Image Guided Biopsies

Authors

  • Pavithra Thandavarayan Department of Pathology, Coimbatore Medical College, Tamilnadu, India
  • Dhanalakshmi Arumugam Department of Pathology, Coimbatore Medical College, Tamilnadu, India
  • Lalitha Chidambaram
  • Lavanya Krishnagiri Balan
  • Shifa Seyed Ibrahim Department of Pathology, Madurai Medical College, Tamilnadu, India

Keywords:

Lung tumor, Non-small cell lung carcinoma, Small cell lung carcinoma, Cytokeratin, TTF-1, p63.

Abstract

Background: Lung  cancer  is  the  leading  cause  of  cancer  related  mortality  in  both  men  and women  worldwide.  Establishing  the  histological  type  and  grade  of  pulmonary  carcinoma  is  very  important  especially  for  the  therapy  and  prognosis.  Study  design:  cross-sectional  descriptive  study. The  study  analyses  various  histomorphological  patterns of  lung  tumors  in correlation  with  immunohistochemical  profile.

Methods: All  the  bronchoscopic  and  CT  guided  needle  biopsy specimens  (50  biopsy  specimens)    received  in  the  Pathology  department  of  Coimbatore  medical  college  hospital  over  a   period  of  one  year  were  analysed.  Both  H&E  and  immunohistochemical  sections  were studied  with  panel  of  markers-  CK7,  CK20,  TTF-1,  chromogranin,  synaptophysin, CD45,  vimentin,  smooth  muscle  actin.

Result: The  most  common  histological  type  was  squamous  cell  carcinoma (48%),  followed  by adenocarcinoma (28%)  and  small  cell  lung  carcinoma (18%).  Large  cell  neuroendocrine carcinoma  and  metastatic  deposit  constituted  2%  each.  Out of 50  cases,  24 cases  were squamous cell carcinoma  which  showed  positivity  with  HMWCK  (20  cases)  and  P63  (22  cases)  (p<0.001).  Fourteen  cases  reported  as  adenocarcinoma  showed  positivity  with  CK7  (14 cases)  and  TTF-1  (13 cases)  (p<0.001).  All  the  nine  cases  of  small  cell carcinomas  showed  positivity  with  both  TTF-1  and  Ki 67.  One  case  of  large  cell carcinoma  with  neuroendocrine  features  showed  immunopositivity  with  neuroendocrine markers.

Conclusion: Integration  of  conventional  histomorphological  diagnosis  with  panel  of  immunohistochemical  markers  allows  more  accurate  identification  of  histological  type, which  has  significant  treatment  implications.

 

DOI: 10.21276/APALM.1342

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Published

01-11-2017

How to Cite

1.
Thandavarayan P, Arumugam D, Chidambaram L, Balan LK, Ibrahim SS. Immunohistochemical Profile of Lung Tumors in Image Guided Biopsies. Ann of Pathol and Lab Med [Internet]. 2017 Nov. 1 [cited 2024 Dec. 20];4(5):A604-609. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1342

Issue

Vol. 4 No. 5 (2017)

Section

Original Article

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Copyright (c) 2017 Pavithra Thandavarayan, Dhanalakshmi Arumugam, Lalitha Chidambaram, Lavanya Krishnagiri Balan, Shifa Seyed Ibrahim

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