Role of platelet indices in differentiating hypoproductive and hyperdestructive thrombocytopenia

Authors

  • Shaheena Parveen Sri Manakula Vinayagar Medical College and Hospital, Puducherry - 605107
  • Mourouguessine Vimal Sri Manakula Vinayagar Medical College and Hospital, Puducherry - 605107

Keywords:

Thrombocytopenia, Platelet Indices, Mean Platelet Volume, Plateletcrit, Platelet Distribution Width

Abstract

Background:During evaluation of thrombocytopenic patients, it is essential to identify the etiology, whether it is due to hypoproduction or hyperdestruction which will have impact on the management. Aim of study is to evaluate the variation and relationship of platelet indices in hypoproductive and hyperdestructive thrombocytopenia patients.

Methods: A cross sectional study for a period of 2 months on Patients with thrombocytopenia. Platelet count, Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV) and relevant clinical details of the thrombocytopenic patients were collected and tested for statistical significance by unpaired t test.

Results:This study included 120 patients of thrombocytopenia who were classified into hypoproductive (26 cases) and hyperdestructive (94 cases). The mean platelet count in hypoproduction group is 75.9 ± 36.4 and in hyperdestruction group is 79.6 ± 36.3 with a P value of 0.64. The mean MPV in hypoproduction group is 10.17 ± 1.3 and in hyperdestruction group is 12.3 ± 0.9 with a significant P value of 0.05. The mean PDW in hypoproduction group is 19.7 ± 5.4 and in hyperdestruction group is 19.3 ± 4.2 with a P value of 0.7. The mean PCT in hypoproduction group is 0.06 ± 0.03 and in hyperdestruction group is 0.08 ± 0.1 with a P value of 0.2.

Conclusion: Mean platelet volume may provide useful information in discriminating the hypoproductive and hyperdestructive thrombocytopenia. Interpretation of platelet indices can help the thrombocytopenic patients in the initial management and can avoid invasive investigations.

 

DOI: 10.21276/APALM.1357

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Published

13-06-2017

How to Cite

1.
Parveen S, Vimal M. Role of platelet indices in differentiating hypoproductive and hyperdestructive thrombocytopenia. Ann of Pathol and Lab Med [Internet]. 2017 Jun. 13 [cited 2024 Dec. 21];4(3):A288-291. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1357

Issue

Vol. 4 No. 3 (2017)

Section

Original Article

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Copyright (c) 2017 Shaheena Parveen, Mourouguessine Vimal

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