Multiple Tuberous Xanthomas: A Diagnostic Dilemma on Cytology
Keywords:
Xanthoma, FNAC, Hyperlipoproteinemias, Cytology.Abstract
Tuberous xanthomas are large nodular lesions that develop in patients with underlying hyperlipoproteinemias. A patient was referred to us for fine needle aspiration cytology (FNAC) from multiple lesions over extensor aspect of upper and lower limbs, which yielded scanty aspirate despite several attempts. This case is being reported to emphasize how such lesions can present as diagnostic challenge on cytology, the role of which has not clearly been described in the previous case reports.
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DOI:Â 10.21276/APALM.1406
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References
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2. Fahey JJ, Stark HH, Donovan WF, et al. Xanthoma of the Achilles tendon: seven cases with familial hyperbetalipoproteinemia. J Bone Joint Surg Am. 1973;55:1197.
3. Singh AJ, Sikarwar S, O P Jatav, and Saify K. Normolipemic tuberous xanthomas.Indian J Dermatol. 2009 (Apr-Jun);54(2):176–179.
4. Zak A, Zeman M, Slaby A and Vecka M: Xanthomas: Clinical and pathophysiological relations. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 158: 181-188, 2014.
5. Sethuraman G, Sugandhan S, Sharma G, Chandramohan K, Chandra NC, Dash SS, Komal A and Sharma VK: Familial homozygous hypercholesterolemia: Report of two patients and review of the literature. Pediatr Dermatol 24: 230-234, 2007.
6. Alves C and Braid Z: Homozygous familial hypercholesterolemia: Case report of a rare cause of dyslipidemia. Pediatr Endocrinol Diabetes Metab 17: 162-165, 2011.
7. Babu R, Venkataram A, Santhosh S, Shivaswamy S. Giant tuberous xanthomas in a case of Type II A Hypercholesterolemia. J Cutan Aesthet Surg. 2012 (Jul-Sep);5(3):204-206.
8. Dagistan E, Canan A, Kizildag B and Barut AY: Multiple tendon xanthomas in patient with heterozygous familial hypercholesterolaemia: Sonographic and MRI findings. BMJ Case Rep 2013: 2013.
9. Szalat R, Arnulf B, Karlin L, Rybojad M, Asli B, Malphettes M, Galicier L, Vignon-Pennamen MD, Harel S, Cordoliani F, et al: Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy. Blood 118: 3777-3784, 2011.
10. Donald S Fredrickson, Robert S Lees. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31(3):321–7.
11. lton KW, Thomas C, Dunkerley DJ: The pathogenesis of xanthomata. J Pathol 1973;109:271.
12. Zhao C et al. Multiple large xanthomas: A Case Report. Oncology Letters 2016, 12 (6): 4327-4332
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Published
11-12-2017
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Bhartiya R, Agrawal P, Kumar R, Dwivedi RP. Multiple Tuberous Xanthomas: A Diagnostic Dilemma on Cytology. Ann of Pathol and Lab Med [Internet]. 2017 Dec. 11 [cited 2025 Feb. 5];4(6):C169-172. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1406
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Copyright (c) 2017 Richa Bhartiya, Pallavi Agrawal, Rajnish Kumar, Rajendra Prasad Dwivedi
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