Incidental findings on liver autopsy with specific emphasis on Hepatitis B

Authors

  • Jaya Ganesh Department of Pathology, Saveetha Medical College and Hospital, Thandalam, Chennai – 602105.
  • Vimal Chander Department of Pathology, Saveetha Medical College and Hospital, Thandalam, Chennai – 602105.
  • J Mahendran Department of Forensic Medicine, Saveetha Medical College and Hospital, Thandalam, Chennai – 602105.

Keywords:

Hepatitis, cirrhosis, orcein stain, steatohepatitis, liver autopsy

Abstract

Background:Silent liver disease is a major cause of morbidity and mortality in the population due to its silent progression to end stage liver disease without significant symptoms. These have to be detected at an earlier stage to reduce the morbidity. This study is aims at correlating the gross and microscopic morphology of 100 liver specimens obtained by autopsy and to correlate with the clinical parameters.

Methods:100 liver specimens obtained by the autopsy of 100 patients, who died of causes like road traffic accidents, poisoning etc. with no medical history during the period from 2007 to 2012, were taken for the study. Histological samples of liver specimens were stained with the routine heamatoxylin and eosin staining, along with special stains like PAS, Reticulin, Perl’s Prussian blue and Orcein staining.

Result:The most common pathology was steatosis (25%) following normal histology (49%), which was followed by chronic venous congestion (12%), chronic hepatitis (6%), cirrhosis (4%), liver cell dysplasia (2%) and metastases (2%). These findings have been correlated with age, sex and special staining. Orcein staining identified ground-glass hepatocytes with detection of Hepatitis B surface antigen in a background of chronic hepatitis and cirrhosis, indication the most probable etiology of Hepatitis B.

Conclusion:This study reiterates the unexpected higher prevalence of NASH among the younger generation and the importance of clinical autopsy in understanding the magnitude of clinically silent liver lesions, mainly Hepatitis B.

 

DOI: 10.21276/APALM.1419

References

1. Brent A, Neuschwander-Tetri et al Non-Alcoholic steatohepatitis. Summary of an AASLD Single topic Conference. J Hepatology 2003;(37):1202 -1219.

2. Mani H, Kleiner DE. Liver Biopsy Findings in Chronic Hepatitis B. Hepatology 2009;49(5):S61-S71.

3. Burton JL. A bite into the history of the autopsy : From ancient roots to modern decay. Forensic Sci Med Pathol 2005 Dec;1(4):277-84.

4. Silas OA, Adoga AA, Manasseh AN, Echejoh GO, Mandong BM, Olu-Silas R. The Role of Necropsy in Diagnostic Dilemmas as Seen in a Tertiary Hospital in North Central Nigeria. Journal of Tropical Medicine 2009 (2009), Article ID 718984. DOI: 10.1155/2009/718984

5. Disibio G, French SW. Metastatic patterns of cancers: results from a large autopsy study. Arch Pathol Lab Med. 2008 Jun;132(6):931-9. DOI: 10.1043/1543-2165

6. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64(1):73-84.

7. Bal MS, Singh SP, Bodal VK, Oberoi SS, Surinder K Pathological findings in Liver Autopsy. JIA Forensic Medicine 2004;26(2):55-57.

8. Sotoudehmanesh R, Sotoudeh M, et al Silent liver diseases in autopsies from Forensic Medicine of Tehran. Arch Iran Med 2006;9(4):324-28.

9. Ghazala Hanif, Abdul Hannan Nagi Incidental findings in the liver – An Autopsy study. Ann King Edward Med Coll 2001;7(1):58-60.

10. Sass DA, Clark K, Grzybicki D, Rabinovitz M, Shaw-Stiffel TA. Diffuse desmoplastic metastatic breast cancer simulating cirrhosis with severe portal hypertension: a case of "pseudocirrhosis". Dig Dis Sci. 2007;52:749–752.

11. Mukhopadhya A, Ramakrishna B, Richard V, Padankatti R, Eapen CE, Chandy GM. Liver histology and immunohistochemical findings in asymptomatic Indians with incidental detection of hepatitis B virus infection. Ind J Gastroenterol 2006;25:128-131.

Downloads

Published

25-10-2017

How to Cite

1.
Ganesh J, Chander V, Mahendran J. Incidental findings on liver autopsy with specific emphasis on Hepatitis B. Ann of Pathol and Lab Med [Internet]. 2017 Oct. 25 [cited 2024 Nov. 19];4(5):A508-514. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1419

Issue

Vol. 4 No. 5 (2017)

Section

Original Article

License

Copyright (c) 2017 Jaya Ganesh, Vimal Chander, J Mahendran

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).