Histopathological Analysis and Correlation of Ki67 and Progesterone Receptor Status with WHO Grading In Meningiomas

Authors

  • Tamilselvi Veeramani Department of Pathology, Karpagam Faculty of Medical Sciences and Research, Othakkalmandabam, Coimbatore.-641032.
  • J Maheswari Department of Pathology KAP DR.Vishwanathan Government Trichy Medical College, Trichy.

Keywords:

Meningioma, progesterone receptor, immunohistochemistry, prognosis.

Abstract

Background: Meningiomas are slow growing tumors that are among the most common of CNS neoplasms and form the most common CNS tumor to be reported above 35 years of age. 

Materials & Methods: This retrospective study was carried out in the Department of Pathology during the period of January2011 to May2013. A total of 50 cases were graded according to the WHO 2016 grading criteria. The biopsy specimens were fixed in 10% neutral buffered formalin, sections was stained with Hematoxylin & Eosin. Immunohistochemistry was done with Progesterone receptor and Ki67 antibodies for selected cases. 

Results: The incidence of meningiomas was 33.11% with a female sex predilection and most common in the 5th decade. Transitional meningioma was the most common variant to occur. The incidence of WHO Grade I, Grade II and Grade III meningiomas were 88%, 4% and 8% respectively. Comparison of Ki67 LI and PR score in various grades of meningiomas were done. The average Ki67 LI and PR score were 1.1%, 10.25; 6%, 3; 16%, 0 in grade I, II and III meningiomas respectively. p value showed a statistically significant difference between different grades of meningiomas with respect to PR and Ki67 status. Spearman correlation showed a clearly significant inverse relationship between the two antibodies. 

Conclusion: The use of immunohistochemical markers aids in determining the aggressive nature of the tumor, its recurrence potential and can be used as prognostic markers.

 

Author Biographies

Tamilselvi Veeramani, Department of Pathology, Karpagam Faculty of Medical Sciences and Research, Othakkalmandabam, Coimbatore.-641032.

Department of Pathology

Assistant Professor

J Maheswari, Department of Pathology KAP DR.Vishwanathan Government Trichy Medical College, Trichy.

Department of Pathology

Assistant Professor

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Published

19-12-2017

How to Cite

1.
Veeramani T, Maheswari J. Histopathological Analysis and Correlation of Ki67 and Progesterone Receptor Status with WHO Grading In Meningiomas. Ann of Pathol and Lab Med [Internet]. 2017 Dec. 19 [cited 2025 Feb. 5];4(6):A714-720. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1499

Issue

Vol. 4 No. 6 (2017)

Section

Original Article

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Copyright (c) 2017 Tamilselvi Veeramani, J Maheswari

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