Secondary Haematological Cancers in Adults: A Single Centre Experience

Authors

  • Vinila Belum Reddy Apollo Institute of Medical Sciences and Research, Hyderabad. India

Keywords:

Second primary malignancy, Second cancers, Second Leukaemia’s, Secondary haematological cancers

Abstract

Introduction: Advances in early detection and treatment mean that more and more people are surviving cancer today. Increased long-term survival seen in patients with solid and hematologic cancers achieved as a result of aggressive chemo radiotherapy has come at a price. Some cancer survivors may develop a new, unrelated cancer later. This is called a second cancer. Reasons for second cancers are varied. Field cancerization, shared environment, familial syndromes, Radiation and Chemotherapy are among the few risk factors affecting the risk of secondary cancers. Therapy-related acute myeloid leukaemia and secondary non-Hodgkin lymphoma has been frequently documented in these patient cohorts. We aim to study the prevalence as well as analyse the factors involved in secondary haematological cancers in our subset of patients.

Methods:  This Cross sectional descriptive study was taken up in Apollo Institute of Medical Sciences and Research, Hyderabad. This is a 5 year observational study. We analysed all patients presenting to the Department of pathology, Apollo Hospitals during the period 2010 to 2015.

Results:  Total 4 cases of Second cancers were documented in our study. Out of which 2 cases were acute myeloid leukaemias and both of them had history of treatment with alkylating agents. The other 2 cases were diagnosed to have secondary Multiple myeloma. Of the patient presenting with multiple myeloma one of them had history of prior Renal cell carcinoma

Conclusion:  Assessment of the risk of second leukaemia should become part of any therapeutic plan for cancer patients. Chemo is known to be a greater risk factor then radiation. Avoidance of drugs with more leukemogenic potential will reduce the occurrence of second leukaemias. It is also important to understand the possibility of a correlation between renal cell carcinoma and multiple myeloma. Field cancerization and increased cytokine expression probably could play an important role in these second cancers.

 

DOI: 10.21276/APALM.1531

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Published

27-10-2017

How to Cite

1.
Reddy VB. Secondary Haematological Cancers in Adults: A Single Centre Experience. Ann of Pathol and Lab Med [Internet]. 2017 Oct. 27 [cited 2024 Nov. 19];4(5):A558-564. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm1531

Issue

Vol. 4 No. 5 (2017)

Section

Original Article

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Copyright (c) 2017 Vinila Belum Reddy

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