Skin Adnexal Tumors: A histopathological study of 60 cases at a tertiary care centre.
Keywords:
Adnexal, Differentiation, Histopathology, Skin.
Abstract
Background: Skin adnexal tumors (SATs) are one of the most challenging areas of dermatopathology. SAT encompasses a large and a diverse group of benign and malignant neoplasms which exhibit morphological differentiation towards one of the different types of adnexal epithelium present in normal skin. The aim of this study is to study the spectrum and microscopic features of skin adnexal tumors.Methods: A cross-sectional, descriptive study was conducted over a period of 5 years in the Department of Pathology, VIMSAR, Burla. Formalin fixed, paraffin embedded tissue sections were stained with hematoxylin and eosin stain for histopathological analysis.Result: Out of total 60 cases diagnosed as adnexal neoplasm 27(45%) tumors were with sweat gland differentiation followed by tumors with sebaceous differentiation 19(31.66%) and follicular differentiation 14(23.33%). The age ranged from 11 years to 75 years and male to female ratio was 1.7:1. Most of the tumors (78.33%) were benign while only 21.66% were malignant. Eccrine poroma was the most common benign tumor while sebaceous carcinoma was the most common malignant tumor.Conclusion: Architectural features are of great importance in differentiating benign tumors from malignant tumors in histopathology.DOI:10.21276/APALM.1787References
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2. Santa Cruz DJ. Tumors of the skin. In: Fletcher CD, editor. Diagnostic Histopathology of Tumors. 3rd ed. Vol. 2. Philadelphia: Churchill Living Stone Elsevier; 2007. pp. 1423–526.
3. Rosai J., “Tumors and tumor like conditions” In:ROSAI AND ACKERMAN^S SURGICAL PATHOLOGY,10th edition.Vol.1. St. Louis,USA:Elsevier Mosby; 2011.p.137
4. Samaila MO. Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med. 2008;7:6-10.
5. Saha A, Das NK, Gharami RC, Chowdhury SN, Datta PK. A clinico-histopathological study of appendageal skin tumors affecting head and neck region in patients attending the dermatology opd of a tertiary care centre in Eastern India. Indian J Dermatol. 2011;56:33–6.
6. Jindal U, Patel R. Study of adnexal tumors of the skin: A three year study of 25 cases. Int J Pathol.2012;13:3.
7. Gayathri SS, Alavandar E, Kumar SA. An analysis of skin appendageal tumors in South India. J Evol Med Dent Sci. 2012;1:907–10.
8. Radhika K, Phaneendra BV, Rukmangadha N, Reddy MK.. A study of biopsy confirmed skin adnexal tumours: Experience at a tertiary care teaching hospital. J Clin Sci Res. 2013;2:132–8.
9. Pantola C, Kala S, Agarwal A, Amit S, Pantola S. Cutaneous adnexal tumours: A clinicopathological descriptive study of 70 cases. World J Pathol. 2013;2:77–82.
10. Sharma A, Paricharak DG, Nigam JS, Rewri S, Soni PB, Omhare A, et al. Histopathological study of skin adnexal tumours-Institutional study in South India. J Skin Cancer. 2014;4:543756.
11. Nair PS. Aclincopathologic study of skin appendageal tumors. Indian J Dermatol Venereol Leprol 2008;74:550.
12. Kaur K, Gupta K, Hemrajani D, Yadav A, Mangal K. Histopathologic analysis of skin adnexal tumors: A three year study of 110 cases at a tertiary care center. Indian J Dermatol 2017;62:400-6
13. El Ochi MR, Boudhas A, Allaoui M, Rharrassi I, Chahadi H, Al Bouzidi A, et al. Skin adnexal tumors : Histological study about 96 cases. Pan Afr Med J 2015;20:389
14. Rajalakshmi V, Selvakumar S, Rajeswari K, Meenakshisundaram K, Veena G, Ramachandran P. Case series of skin adnexal tumors.
15. Kamiya H, Oyama Z, Kitajima Y. “Apocrine” poroma: review of the literature and case report. J Cutan Pathol 2001;28:101–4.
16. Abenoza P, Ackerman A B, Di Leonardo M. Porocarcinoma. In: Neoplasms with Eccrine Differentiation. Lea&Febiger, Philadelphia;1990.p 415-431.
Published
22-03-2018
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