Splenic lymphoma with villous lymphocytes; a case report with review of literature

Authors

  • Ruquiya Afrose senior resident, Department of Pathology JN medical college Aligarh Muslim University Aligarh
  • Mohammad Akram Aligarh Muslim University Aligarh
  • Nirupama Panikar Khan Delhi University
  • Usha Rusia Delhi University

Keywords:

Splenic Lymphoma, Villous Lymphocytes, Leukemia

Abstract

Splenic lymphoma with villous lymphocytes (SLVL) is a rare low-grade B cell non-hodgkin's lymphoma with distinct clinical and morphologic features.

We report a case in a 55 year old man with the diagnosis of Chronic lymphocytic leukemia. On examination patient had no peripheral lymphadenopathy, but had splenomegaly of 2cm below costal margin. Laboratory investigations revealed WBC count 27.9x109/l with an absolute lymphocyte count of 22.3x109/l. Peripheral smear examination showed 80% lymphoid cells, 36% of which showed villous morphology, R-O nucleus, opened up chromatin and no nucleolus. Bone marrow aspirate and biopsy also showed involvement by these villous lymphocytes. These cells were negative for all cytochemical stains including tartrate-resistant acid phosphatase. On flow cytometric immuno-phenotyping these lymphoid cells were highly positive for CD19, CD20, FMC-7, moderately positive for CD10 and negative for CD5, CD23, CD25, CD103 and surface immunoglobulins (SIg) . Based on these findings a diagnosis of SLVL was suggested

 

Author Biographies

Ruquiya Afrose, senior resident, Department of Pathology JN medical college Aligarh Muslim University Aligarh

Department of Pathology
JN medical college
Aligarh Mslim University

Mohammad Akram, Aligarh Muslim University Aligarh

Assistant Professor

Department of Radiotherapy
JN medical college
Aligarh Mslim University

Nirupama Panikar Khan, Delhi University

Associate professor
UCMS & GTB Hospital
New Delhi

Usha Rusia, Delhi University

professor
UCMS & GTB Hospital
New Delhi

References

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Published

12-07-2015

How to Cite

1.
Afrose R, Akram M, Khan NP, Rusia U. Splenic lymphoma with villous lymphocytes; a case report with review of literature. Ann of Pathol and Lab Med [Internet]. 2015 Jul. 12 [cited 2024 Dec. 26];2(3):C200-203. Available from: https://pacificejournals.com/journal/index.php/apalm/article/view/apalm181

Issue

Vol. 2 No. 3 (2015)

Section

Case Report

License

Copyright (c) 2015 Ruquiya Afrose, Mohammad Akram, Nirupama Panikar Khan, Usha Rusia

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